Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing

Hanjun Ryu, Joseph W. Song, Haiwen Luan, Youngmin Sim, Sung Soo Kwak, Hokyung Jang, Young Jin Jo, Hong Joon Yoon, Hyoyoung Jeong, Jaeho Shin, Do Yun Park, Kyeongha Kwon, Guillermo Antonio Ameer*, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio-temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.

Original languageEnglish (US)
Article number2302797
JournalAdvanced Healthcare Materials
Volume13
Issue number5
DOIs
StatePublished - Feb 19 2024

Keywords

  • bioresorbable sensor
  • chronic wound
  • temperature sensor
  • thermal conductivity sensor
  • wireless platform

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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