Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing

Hanjun Ryu; Joseph W. Song; Haiwen Luan; Youngmin Sim; Sung Soo Kwak; Hokyung Jang; Young Jin Jo; Hong Joon Yoon; Hyoyoung Jeong; Jaeho Shin; Do Yun Park; Kyeongha Kwon; Guillermo Antonio Ameer; John A. Rogers

doi:10.1002/adhm.202302797

Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing

Hanjun Ryu, Joseph W. Song, Haiwen Luan, Youngmin Sim, Sung Soo Kwak, Hokyung Jang, Young Jin Jo, Hong Joon Yoon, Hyoyoung Jeong, Jaeho Shin, Do Yun Park, Kyeongha Kwon, Guillermo Antonio Ameer^*, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio-temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.

Original language	English (US)
Article number	2302797
Journal	Advanced Healthcare Materials
Volume	13
Issue number	5
DOIs	https://doi.org/10.1002/adhm.202302797
State	Published - Feb 19 2024

Funding

H.R., J.W.S., H.L., and Y.S. contributed equally to this work. This work made use of the NUFAB facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS‐2025633), the IIN, and Northwestern's MRSEC program (NSF DMR‐1720139). H.R. acknowledges support from the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Nos. RS‐2023‐00244336 and 2020M3H4A1A03084600) and the Technology Innovation Program (20025736, Development of MICS SoC and platform for in vivo implantable electroceutical device) funded By the Ministry of Trade, Industry, and Energy (MOTIE, Korea). J.W.S. acknowledges support from the National Institute of Diabetes and Digestive and Kidney Diseases (grant no. R01DK131302). K.K. acknowledges support by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP; Ministry of Science, ICT & Future Planning; Nos. 2021R1F1A106387111, 2022R1C1C1010555, 2020R1A5A8018367, and BK21).

Keywords

bioresorbable sensor
chronic wound
temperature sensor
thermal conductivity sensor
wireless platform

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/adhm.202302797

Cite this

Ryu, H., Song, J. W., Luan, H., Sim, Y., Kwak, S. S., Jang, H., Jo, Y. J., Yoon, H. J., Jeong, H., Shin, J., Park, D. Y., Kwon, K., Ameer, G. A., & Rogers, J. A. (2024). Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing. Advanced Healthcare Materials, 13(5), Article 2302797. https://doi.org/10.1002/adhm.202302797

@article{8c9941bad51b4fceb5d61e621976e734,

title = "Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing",

abstract = "Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio-temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.",

keywords = "bioresorbable sensor, chronic wound, temperature sensor, thermal conductivity sensor, wireless platform",

author = "Hanjun Ryu and Song, {Joseph W.} and Haiwen Luan and Youngmin Sim and Kwak, {Sung Soo} and Hokyung Jang and Jo, {Young Jin} and Yoon, {Hong Joon} and Hyoyoung Jeong and Jaeho Shin and Park, {Do Yun} and Kyeongha Kwon and Ameer, {Guillermo Antonio} and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.",

year = "2024",

month = feb,

day = "19",

doi = "10.1002/adhm.202302797",

language = "English (US)",

volume = "13",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing

AU - Ryu, Hanjun

AU - Song, Joseph W.

AU - Luan, Haiwen

AU - Sim, Youngmin

AU - Kwak, Sung Soo

AU - Jang, Hokyung

AU - Jo, Young Jin

AU - Yoon, Hong Joon

AU - Jeong, Hyoyoung

AU - Shin, Jaeho

AU - Park, Do Yun

AU - Kwon, Kyeongha

AU - Ameer, Guillermo Antonio

AU - Rogers, John A.

PY - 2024/2/19

Y1 - 2024/2/19

N2 - Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio-temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.

AB - Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio-temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.

KW - bioresorbable sensor

KW - chronic wound

KW - temperature sensor

KW - thermal conductivity sensor

KW - wireless platform

UR - http://www.scopus.com/inward/record.url?scp=85177805239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85177805239&partnerID=8YFLogxK

U2 - 10.1002/adhm.202302797

DO - 10.1002/adhm.202302797

M3 - Article

C2 - 37983897

AN - SCOPUS:85177805239

SN - 2192-2640

VL - 13

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 5

M1 - 2302797

ER -

Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this