Materials Chemistry of Neural Interface Technologies and Recent Advances in Three-Dimensional Systems

Yoonseok Park, Ted S. Chung, Geumbee Lee, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Advances in materials chemistry and engineering serve as the basis for multifunctional neural interfaces that span length scales from individual neurons to neural networks, neural tissues, and complete neural systems. Such technologies exploit electrical, electrochemical, optical, and/or pharmacological modalities in sensing and neuromodulation for fundamental studies in neuroscience research, with additional potential to serve as routes for monitoring and treating neurodegenerative diseases and for rehabilitating patients. This review summarizes the essential role of chemistry in this field of research, with an emphasis on recently published results and developing trends. The focus is on enabling materials in diverse device constructs, including their latest utilization in 3D bioelectronic frameworks formed by 3D printing, self-folding, and mechanically guided assembly. A concluding section highlights key challenges and future directions.

Original languageEnglish (US)
Pages (from-to)5277-5316
Number of pages40
JournalChemical Reviews
Volume122
Issue number5
DOIs
StatePublished - Mar 9 2022

ASJC Scopus subject areas

  • Chemistry(all)

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