Materials Science/Clinical Medi Cine: Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow

R. Chad Webb, Yinji Ma, Siddharth Krishnan, Yuhang Li, Stephen Yoon, Xiaogang Guo, Xue Feng, Yan Shi, Miles Seidel, Nam Heon Cho, Jonas Kurniawan, James Ahad, Niral Sheth, Joseph Kim, James G. TaylorVI, Tom Darlington, Ken Chang, Weizhong Huang, Joshua Ayers, Alexander GruebeleRafal M. Pielak, Marvin J. Slepian, Yonggang Huang, Alexander M. Gorbach, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Continuous monitoring of variations in blood flow is vital in assessing the status of microvascular and macrovascular beds for a wide range of clinical and research scenarios. Although a variety of techniques exist, most require complete immobilization of the subject, thereby limiting their utility to hospital or clinical settings. Those that can be rendered in wearable formats suffer from limited accuracy, motion artifacts, and other shortcomings that follow from an inability to achieve intimate, noninvasive mechanical linkage of sensors with the surface of the skin. We introduce an ultrathin, soft, skin-conforming sensor technology that offers advanced capabilities in continuous and precise blood flow mapping. Systematic work establishes a set of experimental procedures and theoretical models for quantitative measurements and guidelines in design and operation. Experimental studies on human subjects, including validation with measurements performed using state-of-the-art clinical techniques, demonstrate sensitive and accurate assessment of both macrovascular and microvascular flow under a range of physiological conditions. Refined operational modes eliminate long-term drifts and reduce power consumption, thereby providing steps toward the use of this technology for continuous monitoring during daily activities.

Original languageEnglish (US)
Article numbere1500701
JournalScience Advances
Volume1
Issue number9
DOIs
StatePublished - Oct 2015

ASJC Scopus subject areas

  • General

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    Webb, R. C., Ma, Y., Krishnan, S., Li, Y., Yoon, S., Guo, X., Feng, X., Shi, Y., Seidel, M., Cho, N. H., Kurniawan, J., Ahad, J., Sheth, N., Kim, J., TaylorVI, J. G., Darlington, T., Chang, K., Huang, W., Ayers, J., ... Rogers, J. A. (2015). Materials Science/Clinical Medi Cine: Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow. Science Advances, 1(9), [e1500701]. https://doi.org/10.1126/sciadv.1500701