Maternal alcohol and adrenalectomy: Asynchrony of stress response and forced swim behavior

Jennifer L. Slone, Eva E. Redei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Fetal alcohol-exposed (FAE) rats exhibit heightened hormonal and behavioral stress responses, strikingly similar to those caused by exposure to elevated maternal corticosterone (CORT). Since alcohol increases maternal CORT, this study examined the effect of maternal adrenalectomy (ADX) on the CORT stress response and forced swim test (FST) behavior of the adult FAE offspring. Maternal ADX alone dramatically enhanced the CORT stress response of the offspring of pair-fed (PF) mothers but had no effect on the exaggerated CORT response to restraint stress observed in the FAE female. In contrast, maternal ADX reversed the increased immobility of FAE offspring in the FST of depressive behavior. These findings provide original evidence that stress hyper-reactivity and depressive behavior in the FAE offspring are mediated by separate developmental mechanisms.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalNeurotoxicology and Teratology
Issue number2
StatePublished - 2002


  • Corticosterone
  • Fetal alcohol exposure
  • Forced swim test
  • Maternal adrenalectomy

ASJC Scopus subject areas

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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