Maternal and Cord Blood Serum Metabolite Associations with Childhood Adiposity and Body Composition Outcomes

Monica E. Bianco, My H. Vu, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, Denise M. Scholtens, Jami Josefson, William L. Lowe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Maternal metabolites influence the size of newborns independently of maternal body mass index (BMI) and glycemia, highlighting the importance of maternal metabolism on offspring outcomes. This study examined associations of maternal metabolites during pregnancy with childhood adiposity, and cord blood metabolites with childhood adiposity using phenotype and metabolomic data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and the HAPO Follow-Up Study. The maternal metabolites analyses included 2324 mother–offspring pairs, while the cord blood metabolites analyses included 937 offspring. Multiple logistic and linear regression were used to examine associations between primary predictors, maternal or cord blood metabolites, and childhood adiposity outcomes. Multiple maternal fasting and 1 hr metabolites were significantly associated with childhood adiposity outcomes in Model 1 but were no longer significant after adjusting for maternal BMI and/or maternal glycemia. In the fully adjusted model, fasting lactose levels were negatively associated with child BMI z-scores and waist circumference, while fasting urea levels were positively associated with waist circumference. One-hour methionine was positively associated with fat-free mass. There were no significant associations between cord blood metabolites and childhood adiposity outcomes. Few metabolites were associated with childhood adiposity outcomes after adjusting for maternal BMI and glucose, suggesting that maternal BMI accounts for the association between maternal metabolites and childhood adiposity.

Original languageEnglish (US)
Article number749
Issue number6
StatePublished - Jun 2023


  • childhood adiposity
  • childhood outcomes
  • cord blood metabolites
  • maternal metabolites
  • metabolomic
  • offspring outcomes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Maternal and Cord Blood Serum Metabolite Associations with Childhood Adiposity and Body Composition Outcomes'. Together they form a unique fingerprint.

Cite this