Maternal BMI and glycemia impact the fetal metabolome

for the HAPO Study Cooperative Research Group

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads. Research design and Methods Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth. Results: Meta-analysis across the four cohorts demonstrated significant correlation of all cord blood metabolites analyzed with maternal fasting levels of the same metabolites at ∼28 weeks' gestation except for triglycerides, asparagine/aspartate, arginine, and the acylcarnitine C14-OH/C12-DC. Meta-analyses also demonstrated that maternal BMIwith orwithout adjustment formaternal glucosewas associatedwith cord blood metabolites including the branched-chain amino acids and their metabolites as well as phenylalanine. One-hour but not fasting glucose was associated with cord blood 3-hydroxybutyrate and its carnitine ester, a medium-chain acylcarnitine, and glycerol. A number of cord blood metabolites were associated with newborn birth weight and sum of skinfolds, including a negative association of triglycerides and positive association of 3-hydroxybutyrate, its carnitine ester, and serine with both newborn outcomes. Conclusions: Maternal BMI and glycemia are associated with different components of the newborn metabolome, consistent with their independent effects on newborn size at birth.Maternal BMI is associated with a newborn metabolic signature characteristic of insulin resistance and risk of type 2 diabetes in adults.

Original languageEnglish (US)
Pages (from-to)902-910
Number of pages9
JournalDiabetes care
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2017

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Metabolome
Fetal Blood
Mothers
Newborn Infant
Metabolomics
3-Hydroxybutyric Acid
Carnitine
Birth Weight
Meta-Analysis
Fasting
Esters
Triglycerides
Parturition
Social Adjustment
Glucose
Branched Chain Amino Acids
Asparagine
Adiposity
Pregnancy Outcome
Phenylalanine

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

for the HAPO Study Cooperative Research Group (2017). Maternal BMI and glycemia impact the fetal metabolome. Diabetes care, 40(7), 902-910. https://doi.org/10.2337/dc16-2452
for the HAPO Study Cooperative Research Group. / Maternal BMI and glycemia impact the fetal metabolome. In: Diabetes care. 2017 ; Vol. 40, No. 7. pp. 902-910.
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abstract = "Objective: We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads. Research design and Methods Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth. Results: Meta-analysis across the four cohorts demonstrated significant correlation of all cord blood metabolites analyzed with maternal fasting levels of the same metabolites at ∼28 weeks' gestation except for triglycerides, asparagine/aspartate, arginine, and the acylcarnitine C14-OH/C12-DC. Meta-analyses also demonstrated that maternal BMIwith orwithout adjustment formaternal glucosewas associatedwith cord blood metabolites including the branched-chain amino acids and their metabolites as well as phenylalanine. One-hour but not fasting glucose was associated with cord blood 3-hydroxybutyrate and its carnitine ester, a medium-chain acylcarnitine, and glycerol. A number of cord blood metabolites were associated with newborn birth weight and sum of skinfolds, including a negative association of triglycerides and positive association of 3-hydroxybutyrate, its carnitine ester, and serine with both newborn outcomes. Conclusions: Maternal BMI and glycemia are associated with different components of the newborn metabolome, consistent with their independent effects on newborn size at birth.Maternal BMI is associated with a newborn metabolic signature characteristic of insulin resistance and risk of type 2 diabetes in adults.",
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for the HAPO Study Cooperative Research Group 2017, 'Maternal BMI and glycemia impact the fetal metabolome', Diabetes care, vol. 40, no. 7, pp. 902-910. https://doi.org/10.2337/dc16-2452

Maternal BMI and glycemia impact the fetal metabolome. / for the HAPO Study Cooperative Research Group.

In: Diabetes care, Vol. 40, No. 7, 01.07.2017, p. 902-910.

Research output: Contribution to journalArticle

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AU - for the HAPO Study Cooperative Research Group

AU - Lowe, William L.

AU - Bain, James R.

AU - Nodzenski, Michael

AU - Reisetter, Anna C.

AU - Muehlbauer, Michael J.

AU - Stevens, Robert D.

AU - Ilkayeva, Olga R.

AU - Lowe, Lynn P.

AU - Metzger, Boyd E.

AU - Newgard, Christopher B.

AU - Scholtens, Denise M.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective: We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads. Research design and Methods Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth. Results: Meta-analysis across the four cohorts demonstrated significant correlation of all cord blood metabolites analyzed with maternal fasting levels of the same metabolites at ∼28 weeks' gestation except for triglycerides, asparagine/aspartate, arginine, and the acylcarnitine C14-OH/C12-DC. Meta-analyses also demonstrated that maternal BMIwith orwithout adjustment formaternal glucosewas associatedwith cord blood metabolites including the branched-chain amino acids and their metabolites as well as phenylalanine. One-hour but not fasting glucose was associated with cord blood 3-hydroxybutyrate and its carnitine ester, a medium-chain acylcarnitine, and glycerol. A number of cord blood metabolites were associated with newborn birth weight and sum of skinfolds, including a negative association of triglycerides and positive association of 3-hydroxybutyrate, its carnitine ester, and serine with both newborn outcomes. Conclusions: Maternal BMI and glycemia are associated with different components of the newborn metabolome, consistent with their independent effects on newborn size at birth.Maternal BMI is associated with a newborn metabolic signature characteristic of insulin resistance and risk of type 2 diabetes in adults.

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for the HAPO Study Cooperative Research Group. Maternal BMI and glycemia impact the fetal metabolome. Diabetes care. 2017 Jul 1;40(7):902-910. https://doi.org/10.2337/dc16-2452