Abstract
OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62.e1-62.e7 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 207 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2012 |
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Keywords
- body mass index
- gestational diabetes mellitus (GDM)
- glycemia
- obesity
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
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Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. / Stuebe, Alison M.; Landon, Mark B.; Lai, Yinglei; Spong, Catherine Y.; Carpenter, Marshall W.; Ramin, Susan M.; Casey, Brian; Wapner, Ronald J.; Varner, Michael W.; Rouse, Dwight J.; Sciscione, Anthony; Catalano, Patrick; Harper, Margaret; Saade, George; Sorokin, Yoram; Peaceman, Alan M; Tolosa, Jorge E.
In: American Journal of Obstetrics and Gynecology, Vol. 207, No. 1, 01.01.2012, p. 62.e1-62.e7.Research output: Contribution to journal › Article
TY - JOUR
T1 - Maternal BMI, glucose tolerance, and adverse pregnancy outcomes
AU - Stuebe, Alison M.
AU - Landon, Mark B.
AU - Lai, Yinglei
AU - Spong, Catherine Y.
AU - Carpenter, Marshall W.
AU - Ramin, Susan M.
AU - Casey, Brian
AU - Wapner, Ronald J.
AU - Varner, Michael W.
AU - Rouse, Dwight J.
AU - Sciscione, Anthony
AU - Catalano, Patrick
AU - Harper, Margaret
AU - Saade, George
AU - Sorokin, Yoram
AU - Peaceman, Alan M
AU - Tolosa, Jorge E.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
AB - OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
KW - body mass index
KW - gestational diabetes mellitus (GDM)
KW - glycemia
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=84862645832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862645832&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2012.04.035
DO - 10.1016/j.ajog.2012.04.035
M3 - Article
VL - 207
SP - 62.e1-62.e7
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -