Abstract
OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
Original language | English (US) |
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Pages (from-to) | 62.e1-62.e7 |
Journal | American journal of obstetrics and gynecology |
Volume | 207 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2012 |
Funding
Supported by the following grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): nos. HD27915 , HD34116 , HD40485 , HD34208 , HD27869 , HD40500 , HD40560 , HD34136 , HD40544 , HD27860 , HD40545 , HD53097 , HD21410 , HD27917 , HD40512 , HD53118 , and HD36801 ; General Clinical Research Centers grant no. M01-RR00034 ; and National Center for Research Resources grant nos. UL1-RR024989 , M01-RR00080 , UL1-RR025764 , and C06-RR11234 . A.M.S. receives support from the Women's Reproductive Health Research Career Development Center at the University of North Carolina (grant no. 5K12HD050113-04 ).
Keywords
- body mass index
- gestational diabetes mellitus (GDM)
- glycemia
- obesity
ASJC Scopus subject areas
- Obstetrics and Gynecology