Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

Alison M. Stuebe; Mark B. Landon; Yinglei Lai; Catherine Y. Spong; Marshall W. Carpenter; Susan M. Ramin; Brian Casey; Ronald J. Wapner; Michael W. Varner; Dwight J. Rouse; Anthony Sciscione; Patrick Catalano; Margaret Harper; George Saade; Yoram Sorokin; Alan M. Peaceman; Jorge E. Tolosa

doi:10.1016/j.ajog.2012.04.035

Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

Alison M. Stuebe^*, Mark B. Landon, Yinglei Lai, Catherine Y. Spong, Marshall W. Carpenter, Susan M. Ramin, Brian Casey, Ronald J. Wapner, Michael W. Varner, Dwight J. Rouse, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Yoram Sorokin, Alan M. Peaceman, Jorge E. Tolosa

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

Original language	English (US)
Pages (from-to)	62.e1-62.e7
Journal	American journal of obstetrics and gynecology
Volume	207
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2012.04.035
State	Published - Jul 2012

Keywords

body mass index
gestational diabetes mellitus (GDM)
glycemia
obesity

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2012.04.035

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Stuebe, A. M., Landon, M. B., Lai, Y., Spong, C. Y., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Sciscione, A., Catalano, P., Harper, M., Saade, G., Sorokin, Y., Peaceman, A. M., & Tolosa, J. E. (2012). Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. American journal of obstetrics and gynecology, 207(1), 62.e1-62.e7. https://doi.org/10.1016/j.ajog.2012.04.035

Stuebe, Alison M. ; Landon, Mark B. ; Lai, Yinglei ; Spong, Catherine Y. ; Carpenter, Marshall W. ; Ramin, Susan M. ; Casey, Brian ; Wapner, Ronald J. ; Varner, Michael W. ; Rouse, Dwight J. ; Sciscione, Anthony ; Catalano, Patrick ; Harper, Margaret ; Saade, George ; Sorokin, Yoram ; Peaceman, Alan M. ; Tolosa, Jorge E. / Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. In: American journal of obstetrics and gynecology. 2012 ; Vol. 207, No. 1. pp. 62.e1-62.e7.

@article{83a2b634428e4c539fb0bcf4e056e86a,

title = "Maternal BMI, glucose tolerance, and adverse pregnancy outcomes",

abstract = "OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.",

keywords = "body mass index, gestational diabetes mellitus (GDM), glycemia, obesity",

author = "Stuebe, {Alison M.} and Landon, {Mark B.} and Yinglei Lai and Spong, {Catherine Y.} and Carpenter, {Marshall W.} and Ramin, {Susan M.} and Brian Casey and Wapner, {Ronald J.} and Varner, {Michael W.} and Rouse, {Dwight J.} and Anthony Sciscione and Patrick Catalano and Margaret Harper and George Saade and Yoram Sorokin and Peaceman, {Alan M.} and Tolosa, {Jorge E.}",

note = "Funding Information: Supported by the following grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): nos. HD27915 , HD34116 , HD40485 , HD34208 , HD27869 , HD40500 , HD40560 , HD34136 , HD40544 , HD27860 , HD40545 , HD53097 , HD21410 , HD27917 , HD40512 , HD53118 , and HD36801 ; General Clinical Research Centers grant no. M01-RR00034 ; and National Center for Research Resources grant nos. UL1-RR024989 , M01-RR00080 , UL1-RR025764 , and C06-RR11234 . A.M.S. receives support from the Women's Reproductive Health Research Career Development Center at the University of North Carolina (grant no. 5K12HD050113-04 ). ",

year = "2012",

month = jul,

doi = "10.1016/j.ajog.2012.04.035",

language = "English (US)",

volume = "207",

pages = "62.e1--62.e7",

journal = "American Journal of Obstetrics and Gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "1",

}

Stuebe, AM, Landon, MB, Lai, Y, Spong, CY, Carpenter, MW, Ramin, SM, Casey, B, Wapner, RJ, Varner, MW, Rouse, DJ, Sciscione, A, Catalano, P, Harper, M, Saade, G, Sorokin, Y, Peaceman, AM & Tolosa, JE 2012, 'Maternal BMI, glucose tolerance, and adverse pregnancy outcomes', American journal of obstetrics and gynecology, vol. 207, no. 1, pp. 62.e1-62.e7. https://doi.org/10.1016/j.ajog.2012.04.035

Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. / Stuebe, Alison M.; Landon, Mark B.; Lai, Yinglei; Spong, Catherine Y.; Carpenter, Marshall W.; Ramin, Susan M.; Casey, Brian; Wapner, Ronald J.; Varner, Michael W.; Rouse, Dwight J.; Sciscione, Anthony; Catalano, Patrick; Harper, Margaret; Saade, George; Sorokin, Yoram; Peaceman, Alan M.; Tolosa, Jorge E.

In: American journal of obstetrics and gynecology, Vol. 207, No. 1, 07.2012, p. 62.e1-62.e7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

AU - Stuebe, Alison M.

AU - Landon, Mark B.

AU - Lai, Yinglei

AU - Spong, Catherine Y.

AU - Carpenter, Marshall W.

AU - Ramin, Susan M.

AU - Casey, Brian

AU - Wapner, Ronald J.

AU - Varner, Michael W.

AU - Rouse, Dwight J.

AU - Sciscione, Anthony

AU - Catalano, Patrick

AU - Harper, Margaret

AU - Saade, George

AU - Sorokin, Yoram

AU - Peaceman, Alan M.

AU - Tolosa, Jorge E.

N1 - Funding Information: Supported by the following grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): nos. HD27915 , HD34116 , HD40485 , HD34208 , HD27869 , HD40500 , HD40560 , HD34136 , HD40544 , HD27860 , HD40545 , HD53097 , HD21410 , HD27917 , HD40512 , HD53118 , and HD36801 ; General Clinical Research Centers grant no. M01-RR00034 ; and National Center for Research Resources grant nos. UL1-RR024989 , M01-RR00080 , UL1-RR025764 , and C06-RR11234 . A.M.S. receives support from the Women's Reproductive Health Research Career Development Center at the University of North Carolina (grant no. 5K12HD050113-04 ).

PY - 2012/7

Y1 - 2012/7

N2 - OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

AB - OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

KW - body mass index

KW - gestational diabetes mellitus (GDM)

KW - glycemia

KW - obesity

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UR - http://www.scopus.com/inward/citedby.url?scp=84862645832&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2012.04.035

DO - 10.1016/j.ajog.2012.04.035

M3 - Article

C2 - 22609018

AN - SCOPUS:84862645832

VL - 207

SP - 62.e1-62.e7

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -

Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

Abstract

Keywords

ASJC Scopus subject areas

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