Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

Alison M. Stuebe*, Mark B. Landon, Yinglei Lai, Catherine Y. Spong, Marshall W. Carpenter, Susan M. Ramin, Brian Casey, Ronald J. Wapner, Michael W. Varner, Dwight J. Rouse, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Yoram Sorokin, Alan M Peaceman, Jorge E. Tolosa

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

Original languageEnglish (US)
Pages (from-to)62.e1-62.e7
JournalAmerican Journal of Obstetrics and Gynecology
Volume207
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Pregnancy Outcome
Body Mass Index
Mothers
Glucose Tolerance Test
Glucose
Pregnancy Induced Hypertension
Glucose Intolerance
Fasting
Fats
Pregnancy Complications
Adiposity
Gestational Age
Cohort Studies

Keywords

  • body mass index
  • gestational diabetes mellitus (GDM)
  • glycemia
  • obesity

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Stuebe, A. M., Landon, M. B., Lai, Y., Spong, C. Y., Carpenter, M. W., Ramin, S. M., ... Tolosa, J. E. (2012). Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology, 207(1), 62.e1-62.e7. https://doi.org/10.1016/j.ajog.2012.04.035
Stuebe, Alison M. ; Landon, Mark B. ; Lai, Yinglei ; Spong, Catherine Y. ; Carpenter, Marshall W. ; Ramin, Susan M. ; Casey, Brian ; Wapner, Ronald J. ; Varner, Michael W. ; Rouse, Dwight J. ; Sciscione, Anthony ; Catalano, Patrick ; Harper, Margaret ; Saade, George ; Sorokin, Yoram ; Peaceman, Alan M ; Tolosa, Jorge E. / Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. In: American Journal of Obstetrics and Gynecology. 2012 ; Vol. 207, No. 1. pp. 62.e1-62.e7.
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abstract = "OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.",
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Stuebe, AM, Landon, MB, Lai, Y, Spong, CY, Carpenter, MW, Ramin, SM, Casey, B, Wapner, RJ, Varner, MW, Rouse, DJ, Sciscione, A, Catalano, P, Harper, M, Saade, G, Sorokin, Y, Peaceman, AM & Tolosa, JE 2012, 'Maternal BMI, glucose tolerance, and adverse pregnancy outcomes', American Journal of Obstetrics and Gynecology, vol. 207, no. 1, pp. 62.e1-62.e7. https://doi.org/10.1016/j.ajog.2012.04.035

Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. / Stuebe, Alison M.; Landon, Mark B.; Lai, Yinglei; Spong, Catherine Y.; Carpenter, Marshall W.; Ramin, Susan M.; Casey, Brian; Wapner, Ronald J.; Varner, Michael W.; Rouse, Dwight J.; Sciscione, Anthony; Catalano, Patrick; Harper, Margaret; Saade, George; Sorokin, Yoram; Peaceman, Alan M; Tolosa, Jorge E.

In: American Journal of Obstetrics and Gynecology, Vol. 207, No. 1, 01.01.2012, p. 62.e1-62.e7.

Research output: Contribution to journalArticle

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T1 - Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

AU - Stuebe, Alison M.

AU - Landon, Mark B.

AU - Lai, Yinglei

AU - Spong, Catherine Y.

AU - Carpenter, Marshall W.

AU - Ramin, Susan M.

AU - Casey, Brian

AU - Wapner, Ronald J.

AU - Varner, Michael W.

AU - Rouse, Dwight J.

AU - Sciscione, Anthony

AU - Catalano, Patrick

AU - Harper, Margaret

AU - Saade, George

AU - Sorokin, Yoram

AU - Peaceman, Alan M

AU - Tolosa, Jorge E.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

AB - OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

KW - body mass index

KW - gestational diabetes mellitus (GDM)

KW - glycemia

KW - obesity

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Stuebe AM, Landon MB, Lai Y, Spong CY, Carpenter MW, Ramin SM et al. Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology. 2012 Jan 1;207(1):62.e1-62.e7. https://doi.org/10.1016/j.ajog.2012.04.035