Maternal Floor Infarction and Massive Perivillous Fibrin Deposition

Ona Marie Faye-Petersen*, Linda M. Ernst

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPVFD) are pathologically overlapping placental disorders with characteristic gross and shared light microscopic features of excessive perivillous deposition of fibrinoid material. Although rare, they are associated with high rates of fetal growth restriction, perinatal morbidity and mortality, and risks of recurrence with fetal death. The cause of the extensive fibrinoid deposition is unknown, but evidence supports involvement of maternal alloimmune or autoimmune mechanisms. This article presents an updated discussion of features, placental histopathologic differential diagnosis, possible causes, clinical correlates, and adverse outcomes of the MFI/MPVFD spectrum.

Original languageEnglish (US)
Pages (from-to)101-114
Number of pages14
JournalSurgical Pathology Clinics
Issue number1
StatePublished - Mar 1 2013


  • Massive perivillous fibrinoid
  • Maternal floor infarction
  • Perivillous fibrin
  • Placental fibrin
  • Placental infarction
  • Placental ischemia

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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