Maternal gestational diabetes and different indicators of childhood obesity: A large study

Jing Wang, Leishen Wang, Huikun Liu, Shuang Zhang, Junhong Leng, Weiqin Li, Tao Zhang, Nan Li, Wei Li, Andrea A. Baccarelli, Lifang Hou, Gang Hu*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Previous studies found conflicting results about the associations between the exposure to hyperglycemia in utero and the later risks of childhood overweight and obesity. The aim of the present study is to compare the children’s BMI growth between offspring exposed to maternal gestational diabetes mellitus (GDM) and those not exposed and assess the associations between maternal GDM and their offspring’s overweight and obesity risk. We performed a large observational study in 1156 women and their offspring (578 GDM and 578 non-GDM mother–child pairs, matched by their offspring’s gender and age). Maternal GDM was diagnosed according to the World Health Organization criteria. Childhood height, weight, waist circumference, body fat and skinfold were measured using standardized methods. After adjustment for maternal and children’s characteristics, children born to mothers with GDM during pregnancy had higher mean values of Z scores for BMI-for-age, Z scores for weight-for-age, waist circumferences, body fat, subscapular skinfold and suprailiac skinfold, in comparison with their counterparts born to mothers with normal glucose during pregnancy (all P values <0.05). Moreover, maternal GDM was associated with a higher risk of childhood overweight and obesity with multivariate-adjusted odds ratios of 1.42 (95% confidence interval (CI): 1.02–1.97) and 1.18 (95% CI: 1.11–1.24), respectively, compared with the children of mothers without GDM during pregnancy. This study demonstrates that maternal GDM is an independent risk factor of childhood overweight and obesity and is associated with higher BMI in the offspring.

Original languageEnglish (US)
Pages (from-to)1464-1471
Number of pages8
JournalEndocrine Connections
Volume7
Issue number12
DOIs
StatePublished - Jan 1 2018

Fingerprint

Gestational Diabetes
Pediatric Obesity
Mothers
Waist Circumference
Pregnancy
Adipose Tissue
Confidence Intervals
Weights and Measures
Hyperglycemia
Observational Studies
Diabetes Mellitus
Obesity
Odds Ratio
Glucose

Keywords

  • Childhood growth
  • Childhood obesity
  • Early childhood risk factors
  • Gestational diabetes mellitus
  • Maternal glucose levels

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Wang, J., Wang, L., Liu, H., Zhang, S., Leng, J., Li, W., ... Hu, G. (2018). Maternal gestational diabetes and different indicators of childhood obesity: A large study. Endocrine Connections, 7(12), 1464-1471. https://doi.org/10.1530/EC-18-0449
Wang, Jing ; Wang, Leishen ; Liu, Huikun ; Zhang, Shuang ; Leng, Junhong ; Li, Weiqin ; Zhang, Tao ; Li, Nan ; Li, Wei ; Baccarelli, Andrea A. ; Hou, Lifang ; Hu, Gang. / Maternal gestational diabetes and different indicators of childhood obesity : A large study. In: Endocrine Connections. 2018 ; Vol. 7, No. 12. pp. 1464-1471.
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abstract = "Previous studies found conflicting results about the associations between the exposure to hyperglycemia in utero and the later risks of childhood overweight and obesity. The aim of the present study is to compare the children’s BMI growth between offspring exposed to maternal gestational diabetes mellitus (GDM) and those not exposed and assess the associations between maternal GDM and their offspring’s overweight and obesity risk. We performed a large observational study in 1156 women and their offspring (578 GDM and 578 non-GDM mother–child pairs, matched by their offspring’s gender and age). Maternal GDM was diagnosed according to the World Health Organization criteria. Childhood height, weight, waist circumference, body fat and skinfold were measured using standardized methods. After adjustment for maternal and children’s characteristics, children born to mothers with GDM during pregnancy had higher mean values of Z scores for BMI-for-age, Z scores for weight-for-age, waist circumferences, body fat, subscapular skinfold and suprailiac skinfold, in comparison with their counterparts born to mothers with normal glucose during pregnancy (all P values <0.05). Moreover, maternal GDM was associated with a higher risk of childhood overweight and obesity with multivariate-adjusted odds ratios of 1.42 (95{\%} confidence interval (CI): 1.02–1.97) and 1.18 (95{\%} CI: 1.11–1.24), respectively, compared with the children of mothers without GDM during pregnancy. This study demonstrates that maternal GDM is an independent risk factor of childhood overweight and obesity and is associated with higher BMI in the offspring.",
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Wang, J, Wang, L, Liu, H, Zhang, S, Leng, J, Li, W, Zhang, T, Li, N, Li, W, Baccarelli, AA, Hou, L & Hu, G 2018, 'Maternal gestational diabetes and different indicators of childhood obesity: A large study', Endocrine Connections, vol. 7, no. 12, pp. 1464-1471. https://doi.org/10.1530/EC-18-0449

Maternal gestational diabetes and different indicators of childhood obesity : A large study. / Wang, Jing; Wang, Leishen; Liu, Huikun; Zhang, Shuang; Leng, Junhong; Li, Weiqin; Zhang, Tao; Li, Nan; Li, Wei; Baccarelli, Andrea A.; Hou, Lifang; Hu, Gang.

In: Endocrine Connections, Vol. 7, No. 12, 01.01.2018, p. 1464-1471.

Research output: Contribution to journalArticle

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T1 - Maternal gestational diabetes and different indicators of childhood obesity

T2 - A large study

AU - Wang, Jing

AU - Wang, Leishen

AU - Liu, Huikun

AU - Zhang, Shuang

AU - Leng, Junhong

AU - Li, Weiqin

AU - Zhang, Tao

AU - Li, Nan

AU - Li, Wei

AU - Baccarelli, Andrea A.

AU - Hou, Lifang

AU - Hu, Gang

PY - 2018/1/1

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N2 - Previous studies found conflicting results about the associations between the exposure to hyperglycemia in utero and the later risks of childhood overweight and obesity. The aim of the present study is to compare the children’s BMI growth between offspring exposed to maternal gestational diabetes mellitus (GDM) and those not exposed and assess the associations between maternal GDM and their offspring’s overweight and obesity risk. We performed a large observational study in 1156 women and their offspring (578 GDM and 578 non-GDM mother–child pairs, matched by their offspring’s gender and age). Maternal GDM was diagnosed according to the World Health Organization criteria. Childhood height, weight, waist circumference, body fat and skinfold were measured using standardized methods. After adjustment for maternal and children’s characteristics, children born to mothers with GDM during pregnancy had higher mean values of Z scores for BMI-for-age, Z scores for weight-for-age, waist circumferences, body fat, subscapular skinfold and suprailiac skinfold, in comparison with their counterparts born to mothers with normal glucose during pregnancy (all P values <0.05). Moreover, maternal GDM was associated with a higher risk of childhood overweight and obesity with multivariate-adjusted odds ratios of 1.42 (95% confidence interval (CI): 1.02–1.97) and 1.18 (95% CI: 1.11–1.24), respectively, compared with the children of mothers without GDM during pregnancy. This study demonstrates that maternal GDM is an independent risk factor of childhood overweight and obesity and is associated with higher BMI in the offspring.

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KW - Early childhood risk factors

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