Maternal glucocorticoid hormones influence neurotransmitter phenotypic expression in embryos

G. Miller Jonakait*, Martha C. Bohn, Ira B. Black

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Treatment of pregnant rats with reserpine prevented the normal disappearance of catecholamine fluorescence in presumptive neuroblasts of the embryonic gut. These cells normally express the noradrenergic phenotype transiently during embryonic development. The effect of reserpine was reproduced by treating mothers with hydrocortisone acetate. Moreover, the reserpine effect was blocked by treatment with dexamethasone, which inhibits the stress-induced increase in plasma glucocorticoids, and by mitotone, which causes adrenocortical cytolysis. It is concluded that reserpine, through the mediation of maternal glucocorticoid hormones, alters the phenotypic expression of these embryonic neuroblasts.

Original languageEnglish (US)
Pages (from-to)551-553
Number of pages3
Issue number4469
StatePublished - 1980

ASJC Scopus subject areas

  • General


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