TY - JOUR
T1 - Maternal height and child growth patterns
AU - Addo, O. Yaw
AU - Stein, Aryeh D.
AU - Fall, Caroline H.
AU - Gigante, Denise P.
AU - Guntupalli, Aravinda M.
AU - Horta, Bernardo L.
AU - Kuzawa, Christopher W.
AU - Lee, Nanette
AU - Norris, Shane A.
AU - Prabhakaran, Poornima
AU - Richter, Linda M.
AU - Sachdev, Harshpal S.
AU - Martorell, Reynaldo
N1 - Funding Information:
The current COHORTS analysis is supported by the Bill and Melinda Gates Foundation and The Wellcome Trust (United Kingdom). Funding for data collection for the five Cohorts were: Institute of Nutrition of Central America , Panama Nutrition Trial Cohort (Guatemala), US National Institutes of Health , and US National Science Foundation ; Pelotas Birth Cohort (Brazil) Wellcome Trust; New Delhi Birth Cohort Study (India), Indian Council of Medical Research , US National Center for Health Statistics , Medical Research Council (United Kingdom), and British Heart Foundation ; Birth to Twenty Cohort (South Africa), Wellcome Trust , Human Sciences Research Council , South African Medical Research Council , South-African Netherlands Program on Alternative Development , Anglo-American Chairman's Fund and University of the Witwatersrand ; and Cebu Longitudinal Health, and Nutrition Survey (the Philippines) US National Institutes of Health . The authors declare no conflicts of interest.
PY - 2013/8
Y1 - 2013/8
N2 - Objective: To examine associations between maternal height and child growth during 4 developmental periods: intrauterine, birth to age 2 years, age 2 years to mid-childhood (MC), and MC to adulthood. Study design: Pooled analysis of maternal height and offspring growth using 7630 mother-child pairs from 5 birth cohorts (Brazil, Guatemala, India, the Philippines, and South Africa). We used conditional height measures that control for collinearity in height across periods. We estimated associations between maternal height and offspring growth using multivariate regression models adjusted for household income, child sex, birth order, and study site. Results: Maternal height was associated with birth weight and with both height and conditional height at each age examined. The strongest associations with conditional heights were for adulthood and 2 years of age. A 1-cm increase in maternal height predicted a 0.024 (95% CI: 0.021-0.028) SD increase in offspring birth weight, a 0.037 (95% CI: 0.033-0.040) SD increase in conditional height at 2 years, a 0.025 (95% CI: 0.021-0.029 SD increase in conditional height in MC, and a 0.044 (95% CI: 0.040-0.048) SD increase in conditional height in adulthood. Short mothers (<150.1 cm) were more likely to have a child who was stunted at 2 years (prevalence ratio = 3.20 (95% CI: 2.80-3.60) and as an adult (prevalence ratio = 4.74, (95% CI: 4.13-5.44). There was no evidence of heterogeneity by site or sex. Conclusion: Maternal height influences offspring linear growth over the growing period. These influences likely include genetic and non-genetic factors, including nutrition-related intergenerational influences on growth that prevent the attainment of genetic height potential in low- and middle-income countries.
AB - Objective: To examine associations between maternal height and child growth during 4 developmental periods: intrauterine, birth to age 2 years, age 2 years to mid-childhood (MC), and MC to adulthood. Study design: Pooled analysis of maternal height and offspring growth using 7630 mother-child pairs from 5 birth cohorts (Brazil, Guatemala, India, the Philippines, and South Africa). We used conditional height measures that control for collinearity in height across periods. We estimated associations between maternal height and offspring growth using multivariate regression models adjusted for household income, child sex, birth order, and study site. Results: Maternal height was associated with birth weight and with both height and conditional height at each age examined. The strongest associations with conditional heights were for adulthood and 2 years of age. A 1-cm increase in maternal height predicted a 0.024 (95% CI: 0.021-0.028) SD increase in offspring birth weight, a 0.037 (95% CI: 0.033-0.040) SD increase in conditional height at 2 years, a 0.025 (95% CI: 0.021-0.029 SD increase in conditional height in MC, and a 0.044 (95% CI: 0.040-0.048) SD increase in conditional height in adulthood. Short mothers (<150.1 cm) were more likely to have a child who was stunted at 2 years (prevalence ratio = 3.20 (95% CI: 2.80-3.60) and as an adult (prevalence ratio = 4.74, (95% CI: 4.13-5.44). There was no evidence of heterogeneity by site or sex. Conclusion: Maternal height influences offspring linear growth over the growing period. These influences likely include genetic and non-genetic factors, including nutrition-related intergenerational influences on growth that prevent the attainment of genetic height potential in low- and middle-income countries.
KW - COHORTS
KW - Consortium on Health Orientated Research in Transitional Societies
KW - HAZ
KW - Height-for-age z-scores
KW - LMICs
KW - Low- and middle-income countries
KW - MC
KW - MI
KW - Mid-childhood
KW - Multiple imputations
KW - PR
KW - Prevalence ratio
KW - SES
KW - Socioeconomic status
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U2 - 10.1016/j.jpeds.2013.02.002
DO - 10.1016/j.jpeds.2013.02.002
M3 - Article
C2 - 23477997
AN - SCOPUS:84880621928
VL - 163
SP - 549-554.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 2
ER -