Maternal Income during Pregnancy is Associated with Chronic Placental Inflammation at Birth

Lauren S. Keenan-Devlin, Linda M. Ernst, Kharah M. Ross, Sameen Qadir, William A. Grobman, Jane L. Holl, Amy Crockett, Gregory E. Miller, Ann E.B. Borders*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective This study aims to examine whether maternal household income is associated with histological evidence of chronic placental inflammation. Study Design A total of 152 participants completed surveys of household income and consented to placenta collection at delivery and postpartum chart review for birth outcomes. Placental inflammatory lesions were evaluated via histological examination of the membranes, basal plate, and villous parenchyma by a single, experienced pathologist. Associations between household income and the presence of inflammatory lesions were adjusted for known perinatal risk factors. Results Overall, 45% of participants reporting household income below 30,000/y had chronic placental inflammation, compared with 25% of participants reporting income above 100,000 annually (odds ratio [OR] = 4.23, 95% confidence interval [CI] = 1.25, 14.28; p = 0.02). Middle-income groups showed intermediate rates of chronic inflammatory lesions, at 40% for those reporting 30,000 and 50,000 (OR = 3.60, 95% CI = 1.05, 12.53; p = 0.04) and 38% for those reporting 50,000 to 100,000 (OR = 1.57, 95% CI = 0.60, 4.14; p = 0.36). Results remained significant after adjustment for maternal age, race, and marital status. Conclusion Chronic placental inflammation is associated with maternal household income. Greater occurrence of placental lesions in low-income mothers may arise from a systemic inflammatory response to social and physical environmental factors.

Original languageEnglish (US)
Article number160508
Pages (from-to)1003-1010
Number of pages8
JournalAmerican journal of perinatology
Volume34
Issue number10
DOIs
StatePublished - Aug 1 2017

Keywords

  • chronic deciduitis
  • chronic inflammation
  • chronic villitis
  • income
  • placenta
  • pregnancy
  • stress

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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