Maternal Influences over Offspring Allergic Responses

Joan M. Cook-Mills*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Asthma occurs as a result of complex interactions of environmental and genetic factors. Clinical studies and animal models of asthma indicate offspring of allergic mothers have increased risk of development of allergies. Environmental factors including stress-induced corticosterone and vitamin E isoforms during pregnancy regulate the risk for offspring development of allergy. In this review, we discuss mechanisms for the development of allergic disease early in life, environmental factors that may impact the development of risk for allergic disease early in life, and how the variation in global prevalence of asthma may be explained, at least in part, by some environmental components.

Original languageEnglish (US)
JournalCurrent allergy and asthma reports
Volume15
Issue number2
DOIs
StatePublished - Feb 2015

Keywords

  • Allergy
  • Corticosterone
  • Dendritic cells
  • Fetus
  • Neonate
  • α-Tocopherol

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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