Maternal insulin resistance and preeclampsia

John C. Hauth, Rebecca G. Clifton, James M. Roberts, Leslie Myatt, Catherine Y. Spong, Kenneth J. Leveno, Michael W. Varner, Ronald J. Wapner, John M. Thorp, Brian M. Mercer, Alan M Peaceman, Susan M. Ramin, Marshall W. Carpenter, Philip Samuels, Anthony Sciscione, Jorge E. Tolosa, George Saade, Yoram Sorokin, Garland D. Anderson

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine whether mid-trimester insulin resistance is associated with subsequent preeclampsia. Study Design: This was a secondary analysis of 10,154 nulliparous women who received vitamin C and E or placebo daily from 9-16 weeks gestation until delivery. Of these, 1187 women had fasting plasma glucose and insulin tested between 22 and 26 weeks gestation. Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index. Results: Obese women were twice as likely to have a HOMA-IR result of <75th percentile. Hispanic and African American women had a higher percentage at <75th percentile for HOMA-IR than white women (42.2%, 27.2%, and 16.9%, respectively; P < .001). A HOMA-IR result of <75th percentile was higher among the 85 nulliparous women who subsequently had preeclampsia, compared with women who remained normotensive (40.5% vs 24.8%; adjusted odds ratio, 1.9; 95% confidence interval, 1.13.2). Quantitative insulin sensitivity check index results were similar to the HOMA-IR results. Conclusion: Midtrimester maternal insulin resistance is associated with subsequent preeclampsia.

Original languageEnglish (US)
Pages (from-to)327.e1-327.e6
JournalAmerican Journal of Obstetrics and Gynecology
Volume204
Issue number4
DOIs
StatePublished - Jan 1 2011

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Pre-Eclampsia
Insulin Resistance
Mothers
Homeostasis
Pregnancy
Second Pregnancy Trimester
Vitamin E
Hispanic Americans
African Americans
Ascorbic Acid
Fasting
Odds Ratio
Placebos
Confidence Intervals
Insulin
Glucose

Keywords

  • insulin resistance
  • low-risk nulliparous woman
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Hauth, J. C., Clifton, R. G., Roberts, J. M., Myatt, L., Spong, C. Y., Leveno, K. J., ... Anderson, G. D. (2011). Maternal insulin resistance and preeclampsia. American Journal of Obstetrics and Gynecology, 204(4), 327.e1-327.e6. https://doi.org/10.1016/j.ajog.2011.02.024
Hauth, John C. ; Clifton, Rebecca G. ; Roberts, James M. ; Myatt, Leslie ; Spong, Catherine Y. ; Leveno, Kenneth J. ; Varner, Michael W. ; Wapner, Ronald J. ; Thorp, John M. ; Mercer, Brian M. ; Peaceman, Alan M ; Ramin, Susan M. ; Carpenter, Marshall W. ; Samuels, Philip ; Sciscione, Anthony ; Tolosa, Jorge E. ; Saade, George ; Sorokin, Yoram ; Anderson, Garland D. / Maternal insulin resistance and preeclampsia. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 204, No. 4. pp. 327.e1-327.e6.
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abstract = "Objective: The purpose of this study was to determine whether mid-trimester insulin resistance is associated with subsequent preeclampsia. Study Design: This was a secondary analysis of 10,154 nulliparous women who received vitamin C and E or placebo daily from 9-16 weeks gestation until delivery. Of these, 1187 women had fasting plasma glucose and insulin tested between 22 and 26 weeks gestation. Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index. Results: Obese women were twice as likely to have a HOMA-IR result of <75th percentile. Hispanic and African American women had a higher percentage at <75th percentile for HOMA-IR than white women (42.2{\%}, 27.2{\%}, and 16.9{\%}, respectively; P < .001). A HOMA-IR result of <75th percentile was higher among the 85 nulliparous women who subsequently had preeclampsia, compared with women who remained normotensive (40.5{\%} vs 24.8{\%}; adjusted odds ratio, 1.9; 95{\%} confidence interval, 1.13.2). Quantitative insulin sensitivity check index results were similar to the HOMA-IR results. Conclusion: Midtrimester maternal insulin resistance is associated with subsequent preeclampsia.",
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Hauth, JC, Clifton, RG, Roberts, JM, Myatt, L, Spong, CY, Leveno, KJ, Varner, MW, Wapner, RJ, Thorp, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Carpenter, MW, Samuels, P, Sciscione, A, Tolosa, JE, Saade, G, Sorokin, Y & Anderson, GD 2011, 'Maternal insulin resistance and preeclampsia', American Journal of Obstetrics and Gynecology, vol. 204, no. 4, pp. 327.e1-327.e6. https://doi.org/10.1016/j.ajog.2011.02.024

Maternal insulin resistance and preeclampsia. / Hauth, John C.; Clifton, Rebecca G.; Roberts, James M.; Myatt, Leslie; Spong, Catherine Y.; Leveno, Kenneth J.; Varner, Michael W.; Wapner, Ronald J.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M; Ramin, Susan M.; Carpenter, Marshall W.; Samuels, Philip; Sciscione, Anthony; Tolosa, Jorge E.; Saade, George; Sorokin, Yoram; Anderson, Garland D.

In: American Journal of Obstetrics and Gynecology, Vol. 204, No. 4, 01.01.2011, p. 327.e1-327.e6.

Research output: Contribution to journalArticle

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T1 - Maternal insulin resistance and preeclampsia

AU - Hauth, John C.

AU - Clifton, Rebecca G.

AU - Roberts, James M.

AU - Myatt, Leslie

AU - Spong, Catherine Y.

AU - Leveno, Kenneth J.

AU - Varner, Michael W.

AU - Wapner, Ronald J.

AU - Thorp, John M.

AU - Mercer, Brian M.

AU - Peaceman, Alan M

AU - Ramin, Susan M.

AU - Carpenter, Marshall W.

AU - Samuels, Philip

AU - Sciscione, Anthony

AU - Tolosa, Jorge E.

AU - Saade, George

AU - Sorokin, Yoram

AU - Anderson, Garland D.

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N2 - Objective: The purpose of this study was to determine whether mid-trimester insulin resistance is associated with subsequent preeclampsia. Study Design: This was a secondary analysis of 10,154 nulliparous women who received vitamin C and E or placebo daily from 9-16 weeks gestation until delivery. Of these, 1187 women had fasting plasma glucose and insulin tested between 22 and 26 weeks gestation. Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index. Results: Obese women were twice as likely to have a HOMA-IR result of <75th percentile. Hispanic and African American women had a higher percentage at <75th percentile for HOMA-IR than white women (42.2%, 27.2%, and 16.9%, respectively; P < .001). A HOMA-IR result of <75th percentile was higher among the 85 nulliparous women who subsequently had preeclampsia, compared with women who remained normotensive (40.5% vs 24.8%; adjusted odds ratio, 1.9; 95% confidence interval, 1.13.2). Quantitative insulin sensitivity check index results were similar to the HOMA-IR results. Conclusion: Midtrimester maternal insulin resistance is associated with subsequent preeclampsia.

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Hauth JC, Clifton RG, Roberts JM, Myatt L, Spong CY, Leveno KJ et al. Maternal insulin resistance and preeclampsia. American Journal of Obstetrics and Gynecology. 2011 Jan 1;204(4):327.e1-327.e6. https://doi.org/10.1016/j.ajog.2011.02.024