Maternal Intake of Folic Acid and Neural Crest Stem Cells

Chandra S. Mayanil*, Shunsuke Ichi, Barbara Mania Farnell, Vanda Boshnjaku, Tadanori Tomita, David G. McLone

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Maternal folic acid (FA) intake has beneficial effects in preventing neural tube defects and may also play a role in the prevention of adult onset diseases such as Alzheimer's disease, dementia, neuropsychiatric disorders, cardiovascular diseases, and cerebral ischemia. This review will focus on the effects of maternal FA intake on neural crest stem cell proliferation and differentiation. Although FA is generally considered beneficial, it has the potential of promoting cell proliferation at the expense of differentiation. In some situations, this may lead to miscarriage or postnatal developmental abnormalities. Therefore, a blind approach such as " FA for everyone" is not necessarily the best course of action. Ultimately, the best approach for FA supplementation, and potentially other nutritional supplements, will include customized patient genomic profiles for determining dose and duration.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc
Pages143-173
Number of pages31
DOIs
StatePublished - 2011

Publication series

NameVitamins and Hormones
Volume87
ISSN (Print)0083-6729

Keywords

  • Chromatin
  • Differentiation
  • Folic acid
  • Histone
  • MiRNA
  • Neurogenesis

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

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