Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

for the HAPO Study Cooperative Research Group

Research output: Contribution to journalArticle

Abstract

Aims/hypothesis: We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads. Methods: Targeted and non-targeted metabolomics assays were performed on fasting and 1 h serum samples from a total of 1600 mothers in four ancestry groups (Northern European, Afro-Caribbean, Mexican American and Thai) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, underwent an OGTT at ~28 weeks gestation and whose newborns had anthropometric measurements at birth. Results: In this observational study, meta-analyses demonstrated significant associations of maternal fasting and 1 h metabolites with birthweight, cord C-peptide and/or sum of skinfolds across ancestry groups. In particular, maternal fasting triacylglycerols were associated with newborn sum of skinfolds. At 1 h, several amino acids, fatty acids and lipid metabolites were associated with one or more newborn outcomes. Network analyses revealed clusters of fasting acylcarnitines, amino acids, lipids and fatty acid metabolites associated with cord C-peptide and sum of skinfolds, with the addition of branched-chain and aromatic amino acids at 1 h. Conclusions/interpretation: The maternal metabolome during pregnancy is associated with newborn outcomes. Maternal levels of amino acids, acylcarnitines, lipids and fatty acids and their metabolites during pregnancy relate to fetal growth, adiposity and cord C-peptide, independent of maternal BMI and blood glucose levels.

Original languageEnglish (US)
Pages (from-to)473-484
Number of pages12
JournalDiabetologia
Volume62
Issue number3
DOIs
StatePublished - Mar 1 2019

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Hyperinsulinism
Mothers
Newborn Infant
Pregnancy
C-Peptide
Fasting
Fatty Acids
Adiposity
Lipids
Amino Acids
Branched Chain Amino Acids
Aromatic Amino Acids
Metabolomics
Metabolome
Pregnancy Outcome
Glucose Tolerance Test
Fetal Development
Hyperglycemia
Observational Studies
Cluster Analysis

Keywords

  • Adiposity
  • Fetal growth
  • Metabolomics
  • Pregnancy outcomes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

for the HAPO Study Cooperative Research Group. / Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries. In: Diabetologia. 2019 ; Vol. 62, No. 3. pp. 473-484.
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Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries. / for the HAPO Study Cooperative Research Group.

In: Diabetologia, Vol. 62, No. 3, 01.03.2019, p. 473-484.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

AU - for the HAPO Study Cooperative Research Group

AU - Kadakia, Rachel Bulbul

AU - Nodzenski, Michael

AU - Talbot, Octavious

AU - Kuang, Alan

AU - Bain, James R.

AU - Muehlbauer, Michael J.

AU - Stevens, Robert D.

AU - Ilkayeva, Olga R.

AU - O’Neal, Sara K.

AU - Lowe, Lynn Peterson

AU - Metzger, Boyd E

AU - Newgard, Christopher B.

AU - Scholtens, Denise M

AU - Lowe Jr, William L

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Aims/hypothesis: We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads. Methods: Targeted and non-targeted metabolomics assays were performed on fasting and 1 h serum samples from a total of 1600 mothers in four ancestry groups (Northern European, Afro-Caribbean, Mexican American and Thai) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, underwent an OGTT at ~28 weeks gestation and whose newborns had anthropometric measurements at birth. Results: In this observational study, meta-analyses demonstrated significant associations of maternal fasting and 1 h metabolites with birthweight, cord C-peptide and/or sum of skinfolds across ancestry groups. In particular, maternal fasting triacylglycerols were associated with newborn sum of skinfolds. At 1 h, several amino acids, fatty acids and lipid metabolites were associated with one or more newborn outcomes. Network analyses revealed clusters of fasting acylcarnitines, amino acids, lipids and fatty acid metabolites associated with cord C-peptide and sum of skinfolds, with the addition of branched-chain and aromatic amino acids at 1 h. Conclusions/interpretation: The maternal metabolome during pregnancy is associated with newborn outcomes. Maternal levels of amino acids, acylcarnitines, lipids and fatty acids and their metabolites during pregnancy relate to fetal growth, adiposity and cord C-peptide, independent of maternal BMI and blood glucose levels.

AB - Aims/hypothesis: We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads. Methods: Targeted and non-targeted metabolomics assays were performed on fasting and 1 h serum samples from a total of 1600 mothers in four ancestry groups (Northern European, Afro-Caribbean, Mexican American and Thai) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, underwent an OGTT at ~28 weeks gestation and whose newborns had anthropometric measurements at birth. Results: In this observational study, meta-analyses demonstrated significant associations of maternal fasting and 1 h metabolites with birthweight, cord C-peptide and/or sum of skinfolds across ancestry groups. In particular, maternal fasting triacylglycerols were associated with newborn sum of skinfolds. At 1 h, several amino acids, fatty acids and lipid metabolites were associated with one or more newborn outcomes. Network analyses revealed clusters of fasting acylcarnitines, amino acids, lipids and fatty acid metabolites associated with cord C-peptide and sum of skinfolds, with the addition of branched-chain and aromatic amino acids at 1 h. Conclusions/interpretation: The maternal metabolome during pregnancy is associated with newborn outcomes. Maternal levels of amino acids, acylcarnitines, lipids and fatty acids and their metabolites during pregnancy relate to fetal growth, adiposity and cord C-peptide, independent of maternal BMI and blood glucose levels.

KW - Adiposity

KW - Fetal growth

KW - Metabolomics

KW - Pregnancy outcomes

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