Maternal serum α-fetoprotein screening in North Carolina: Experience with more than twelve thousand pregnancies

B. K. Burton, S. G. Sowers, L. H. Nelson

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

A total of 12,084 patients participated in a maternal serum α-fetoprotein screening program in central North Carolina between July 1, 1978, and June 30, 1982. Fifteen open neural tube defects were detected and three others were issed, resulting in a detection rate of 83%. With a cutoff of 2.5 times the normal median, 3.7% of patients screened had a single maternal serum AFP elevation, 2.1% had two successive elevations, and 1.2% became candidates for amniocentesis. Of these patients offered amniocentesis, one in 10 was found to have a fetus with a neural tube defect. No normal fetuses have been aborted. Patients with maternal serum AFP elevations were soon to have a substantially increased risk of fetal loss. Low maternal serum AFP levels were also a significant finding and led to recognition of less advanced gestational age, fetal death, or molar pregnancy in a number of cases.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume146
Issue number4
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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