Maternal serum analyte levels after first-trimester multifetal pregnancy reduction

L. P. Shulman*, O. P. Phillips, T. A. Cervetti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

OBJECTIVE: Our purpose was to assess the effect of multifetal pregnancy reduction on maternal serum levels of analytes used for screening low-risk women for fetal chromosome abnormalities and neural tube defects. STUDY DESIGN: Peripheral blood samples were obtained between 15.0 and 20.9 weeks' gestation from 10 consecutive women who had undergone first-trimester multifetal pregnancy reduction. The samples were assayed for levels of α- fetoprotein, human chorionic gonadotropin, and unconjugated estriol. Analyte concentrations were interpreted within our maternal serum screening program. RESULTS: Levels of α-fetoprotein were significantly elevated in all samples. In each pregnancy levels of human chorionic gonadotropin and unconjugated estriol were consistent with the number of continuing gestations. CONCLUSIONS: First-trimester multifetal reduction does not alter second- trimester levels of human chorionic gonadotropin and unconjugated estriol. Further study is needed to determine whether these analytes could be used to screen pregnancies for fetal chromosome abnormalities after first-trimester multifetal reduction.

Original languageEnglish (US)
Pages (from-to)1072-1074
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Volume174
Issue number3
DOIs
StatePublished - Jan 1 1996

Keywords

  • Multifetal reduction
  • human chorionic gonadotropin
  • maternal serum screening
  • unconjugated estriol
  • α-fetoprotein

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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