TY - JOUR
T1 - Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns
AU - Priyadarshini, Medha
AU - Thomas, Alexandra
AU - Reisetter, Anna C.
AU - Scholtens, Denise M.
AU - Wolever, Thomas M S
AU - Josefson, Jami L.
AU - Layden, Brian T.
N1 - Funding Information:
BTL is supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Career Development (grant no. 1IK2BX001587-01 ). JJ is supported by grant no. K12 HD055884 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development .
PY - 2014/8
Y1 - 2014/8
N2 - During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation, we investigated whether serum SCFA levels during pregnancy are related to key metabolic parameters in mothers and newborns. In this prospective study, 20 pregnant women without gestational diabetes were evaluated at 36-38 weeks of gestation, and their newborns were assessed after parturition. In this cohort, which included normal (n = 10) and obese (n = 10) subjects based on prepregnancy body mass index, serum levels of SCFAs (acetate, propionate, and butyrate), maternal adipokines, maternal glucose, and C-peptide were measured at 36-38 weeks of gestation. Maternal weight gain and newborn anthropometrics were also determined. Data were analyzed using linear regression to test for associations, adjusting for prepregnancy obesity. In this cohort, serum acetate levels were associated with maternal weight gain and maternal adiponectin levels. In addition, serum propionate correlated negatively with maternal leptin levels, newborn length, and body weight. Taken together, this study observed that novel relationships exist among maternal SCFA levels and multiple interrelated maternal/newborn metabolic parameters.
AB - During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation, we investigated whether serum SCFA levels during pregnancy are related to key metabolic parameters in mothers and newborns. In this prospective study, 20 pregnant women without gestational diabetes were evaluated at 36-38 weeks of gestation, and their newborns were assessed after parturition. In this cohort, which included normal (n = 10) and obese (n = 10) subjects based on prepregnancy body mass index, serum levels of SCFAs (acetate, propionate, and butyrate), maternal adipokines, maternal glucose, and C-peptide were measured at 36-38 weeks of gestation. Maternal weight gain and newborn anthropometrics were also determined. Data were analyzed using linear regression to test for associations, adjusting for prepregnancy obesity. In this cohort, serum acetate levels were associated with maternal weight gain and maternal adiponectin levels. In addition, serum propionate correlated negatively with maternal leptin levels, newborn length, and body weight. Taken together, this study observed that novel relationships exist among maternal SCFA levels and multiple interrelated maternal/newborn metabolic parameters.
KW - Abbreviations
KW - BMI
KW - SCFA
KW - body mass index
KW - short-chain fatty acid
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U2 - 10.1016/j.trsl.2014.01.012
DO - 10.1016/j.trsl.2014.01.012
M3 - Article
C2 - 24530607
AN - SCOPUS:84904815142
SN - 1931-5244
VL - 164
SP - 153
EP - 157
JO - Translational Research
JF - Translational Research
IS - 2
ER -
