Changes in the pulmonary uptake of various lipophilic amine drugs have been thought to reveal microvascular and lung tissue composition changes associated with lung injury. To investigate this potential we developed a kinetic model for the pulmonary disposition of lipophilic amine drugs that accomodates lung perfusion heterogeneity and the drug's characteristics that impact on its lung tissue disposition. Venous concentration (cone.) curves were determined after a 14C-lido bolus inj. into the pulmonary artery of the IPL at different perfusate flows and perfusate albumin cones.. Relative to the vascular reference indicator (FITC dextran) the lido peak cone, was delayed and its extraction decreased at increased flow (see fig) or increased perfusate albumin cone.. Reasonable fits of the model to the data (see fig) were obtained with a model that included both a rapidly and a slowly equilibrating association of drug with lung tissue and a rapid association of drug with the perfusate protein Supported by Dept. Veterans Affairs.
|Original language||English (US)|
|State||Published - Dec 1 1996|
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology