Mathematical modeling of directional effects of perfusion on liver tissue temperature of radio frequency ablation

T. Peng*, D. P. O'Neill, S. J. Payne, Claire Bost, Ronan Flanagan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Thermal ablation of a tumor in the liver with Radio Frequency energy can be accomplished by using a probe inserted into the tissue under the guidance of CT imaging. The extent of ablation can be significantly affected by the heat loss due to the high perfusion in the liver, especially when the tumor is located close a large vessel. A mathematical model is thus presented here to investigate the heat sinking effect of a large vessel, combing of a 3D two-equation coupled bio-heat model and a 1D model of convective heat transport across the blood vessel surface. It has been found that the length of the ablation duration and the amount of ablation power highly depend on the distance between the ablation probe and the large vessel. Moreover, based on the model simulation in the study, the ablation of tissue around a large vessel under temperature control mode could lead to excessive power input and thus an oversized lesion zone.

Original languageEnglish (US)
Title of host publication6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Pages740-743
Number of pages4
Volume31 IFMBE
DOIs
StatePublished - Oct 22 2010
Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore
Duration: Aug 1 2010Aug 6 2010

Other

Other6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
CountrySingapore
CitySingapore
Period8/1/108/6/10

Keywords

  • bio-heat transport
  • computational modeling
  • Radio Frequency Ablation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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