TY - JOUR
T1 - Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration
AU - Goldberg, M.
AU - Lacerda-Pinheiro, S.
AU - Priam, F.
AU - Jegat, N.
AU - Six, N.
AU - Bonnefoix, M.
AU - Septier, D.
AU - Chaussain-Miller, C.
AU - Veis, A.
AU - Denbesten, P.
AU - Poliard, A.
N1 - Funding Information:
Acknowledgements These investigations were carried out with the support of a CNRS/INSERM grant (Ingénierie tissulaire 2000), INSERM grant Cellules souches adultes 2003 and Fondation de l'Avenir ETS-407). This article is dedicated to more than 25 years of friendship between the first author and Prof. Dr. Gottfried Schmalz.
PY - 2008/6
Y1 - 2008/6
N2 - This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.
AB - This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.
KW - Dentin
KW - Matricellular molecules
KW - Odontoblast progenitors
KW - Pulp
KW - Regeneration
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U2 - 10.1007/s00784-007-0172-6
DO - 10.1007/s00784-007-0172-6
M3 - Review article
C2 - 18157557
AN - SCOPUS:43049138804
SN - 1432-6981
VL - 12
SP - 109
EP - 112
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
IS - 2
ER -