Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration

M. Goldberg*, S. Lacerda-Pinheiro, F. Priam, N. Jegat, N. Six, M. Bonnefoix, D. Septier, C. Chaussain-Miller, A. Veis, P. Denbesten, A. Poliard

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalClinical Oral Investigations
Issue number2
StatePublished - Jun 2008


  • Dentin
  • Matricellular molecules
  • Odontoblast progenitors
  • Pulp
  • Regeneration

ASJC Scopus subject areas

  • Dentistry(all)


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