Matricellular proteins in the trabecular meshwork

Douglas J. Rhee*, Ramez I. Haddadin, Min Hyung Kang, Dong Jin Oh

*Corresponding author for this work

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

The trabecular meshwork is one of the primary tissues of interest in the normal regulation and dysregulation of intraocular pressure (IOP) that is a causative risk factor for primary open-angle glaucoma. Matricellular proteins generally function to allow cells to modulate their attachments with and alter the characteristics of their surrounding extracellular matrix (ECM). In non-ocular tissues, matricellular proteins generally increase fibrosis. Since ECM turnover is very important to the outflow facility, matricellular proteins may have a significant role in the regulation of IOP. The formalized study of matricellular proteins in trabecular meshwork is in its infancy. SPARC, thrombospondins-1 and -2, and tenascins-C and -X, and osteopontin have been localized to varying areas within the trabecular meshwork. Preliminary evidence indicates that SPARC and thrombospondin-1 play a role in the regulation of IOP and possibly the pathophysiology of glaucoma. These data show promise that matricellular proteins are involved in IOP dysregulation and are potential therapeutic targets. Further study is needed to clarify these roles.

Original languageEnglish (US)
Pages (from-to)694-703
Number of pages10
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009

Fingerprint

Trabecular Meshwork
Intraocular Pressure
Proteins
Extracellular Matrix
Thrombospondin 1
Thrombospondins
Tenascin
Osteopontin
Glaucoma
Fibrosis

Keywords

  • SPARC
  • extracellular matrix
  • galectin
  • hevin
  • matricellular proteins
  • osteopontin
  • tenascin
  • thrombospondin
  • trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Rhee, Douglas J. ; Haddadin, Ramez I. ; Kang, Min Hyung ; Oh, Dong Jin. / Matricellular proteins in the trabecular meshwork. In: Experimental Eye Research. 2009 ; Vol. 88, No. 4. pp. 694-703.
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Matricellular proteins in the trabecular meshwork. / Rhee, Douglas J.; Haddadin, Ramez I.; Kang, Min Hyung; Oh, Dong Jin.

In: Experimental Eye Research, Vol. 88, No. 4, 30.04.2009, p. 694-703.

Research output: Contribution to journalReview article

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AU - Rhee, Douglas J.

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AB - The trabecular meshwork is one of the primary tissues of interest in the normal regulation and dysregulation of intraocular pressure (IOP) that is a causative risk factor for primary open-angle glaucoma. Matricellular proteins generally function to allow cells to modulate their attachments with and alter the characteristics of their surrounding extracellular matrix (ECM). In non-ocular tissues, matricellular proteins generally increase fibrosis. Since ECM turnover is very important to the outflow facility, matricellular proteins may have a significant role in the regulation of IOP. The formalized study of matricellular proteins in trabecular meshwork is in its infancy. SPARC, thrombospondins-1 and -2, and tenascins-C and -X, and osteopontin have been localized to varying areas within the trabecular meshwork. Preliminary evidence indicates that SPARC and thrombospondin-1 play a role in the regulation of IOP and possibly the pathophysiology of glaucoma. These data show promise that matricellular proteins are involved in IOP dysregulation and are potential therapeutic targets. Further study is needed to clarify these roles.

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