Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status

Suyang Li, Ying Wu, Sheila M. Keating, Hongyan Du, Christina L. Sammet, Cindy Zadikoff, Riti Mahadevia, Leon G. Epstein, Ann B. Ragin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Matrix metalloproteinases (MMPs) have been implicated in human immunodeficiency virus (HIV)-associated neurological injury; however, this relationship has not been studied early in infection. Plasma levels of MMP-1, MMP-2, MMP-7, MMP-9, and MMP-10 measured using Luminex technology (Austin, TX, USA) were compared in 52 HIV and 21 seronegative participants of the Chicago Early HIV Infection study. MMP levels were also examined in HIV subgroups defined by antibody reactivity, viremia, and antiretroviral status, as well as in available cerebrospinal fluid (CSF) samples (n = 9). MMPs were evaluated for patterns of relationship to cognitive function and to quantitative magnetic resonance measurements of the brain derived in vivo. Plasma MMP-2 levels were significantly reduced in early HIV infection and correlated with altered white matter integrity and atrophic brain changes. MMP-9 levels were higher in the treated subgroup than in the naïve HIV subgroup. Only MMP-2 and MMP-9 were detected in the CSF; CSF MMP-2 correlated with white matter integrity and with volumetric changes in basal ganglia. Relationships with cognitive function were also identified. MMP-2 levels in plasma and in CSF correspond to early changes in brain structure and function. These findings establish a link between MMPs and neurological status previously unidentified in early HIV infection.

Original languageEnglish (US)
Pages (from-to)452-460
Number of pages9
JournalJournal of neurovirology
Issue number5
StatePublished - Oct 2013


  • Acute HIV
  • Diffusion tensor imaging
  • HIV-associated neurocognitive disorder
  • Matrix metalloproteinases
  • Neuro-AIDS

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology


Dive into the research topics of 'Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status'. Together they form a unique fingerprint.

Cite this