TY - JOUR
T1 - Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption
AU - Herrera, Iliana
AU - Cisneros, José
AU - Maldonado, Mariel
AU - Ramírez, Remedios
AU - Ortiz-Quintero, Blanca
AU - Anso, Elena
AU - Chandel, Navdeep S.
AU - Selman, Moisés
AU - Pardo, Annie
PY - 2013/9/6
Y1 - 2013/9/6
N2 - Background: In IPF MMP-1 is up-regulated and expressed in alveolar epithelial cells. Result: Transfection of MMP-1 in MLE cells increased proliferation/migration, protected from apoptosis, repressed oxygen consumption ratio and ROS production, and stimulated HIF-1. Conclusion: MMP-1 inhibits mitochondrial function and contributes to a proliferative/migratory and anti-apoptotic phenotype. Significance: MMP-1 promotes the Warburg effect characterized by increased aerobic glycolysis and HIF-1 during normoxia.
AB - Background: In IPF MMP-1 is up-regulated and expressed in alveolar epithelial cells. Result: Transfection of MMP-1 in MLE cells increased proliferation/migration, protected from apoptosis, repressed oxygen consumption ratio and ROS production, and stimulated HIF-1. Conclusion: MMP-1 inhibits mitochondrial function and contributes to a proliferative/migratory and anti-apoptotic phenotype. Significance: MMP-1 promotes the Warburg effect characterized by increased aerobic glycolysis and HIF-1 during normoxia.
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U2 - 10.1074/jbc.M113.459784
DO - 10.1074/jbc.M113.459784
M3 - Article
C2 - 23902766
AN - SCOPUS:84883709167
SN - 0021-9258
VL - 288
SP - 25964
EP - 25975
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 36
ER -