Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption

Iliana Herrera, José Cisneros, Mariel Maldonado, Remedios Ramírez, Blanca Ortiz-Quintero, Elena Anso, Navdeep Chandel, Moisés Selman, Annie Pardo*

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: In IPF MMP-1 is up-regulated and expressed in alveolar epithelial cells. Result: Transfection of MMP-1 in MLE cells increased proliferation/migration, protected from apoptosis, repressed oxygen consumption ratio and ROS production, and stimulated HIF-1. Conclusion: MMP-1 inhibits mitochondrial function and contributes to a proliferative/migratory and anti-apoptotic phenotype. Significance: MMP-1 promotes the Warburg effect characterized by increased aerobic glycolysis and HIF-1 during normoxia.

Original languageEnglish (US)
Pages (from-to)25964-25975
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

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Alveolar Epithelial Cells
Matrix Metalloproteinase 1
Oxygen Consumption
Cell Movement
Cell Proliferation
Apoptosis
Oxygen
Lung
Maximum likelihood estimation
Cell proliferation
Glycolysis
Transfection
Phenotype
Epithelial Cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Herrera, Iliana ; Cisneros, José ; Maldonado, Mariel ; Ramírez, Remedios ; Ortiz-Quintero, Blanca ; Anso, Elena ; Chandel, Navdeep ; Selman, Moisés ; Pardo, Annie. / Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 36. pp. 25964-25975.
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Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption. / Herrera, Iliana; Cisneros, José; Maldonado, Mariel; Ramírez, Remedios; Ortiz-Quintero, Blanca; Anso, Elena; Chandel, Navdeep; Selman, Moisés; Pardo, Annie.

In: Journal of Biological Chemistry, Vol. 288, No. 36, 06.09.2013, p. 25964-25975.

Research output: Contribution to journalArticle

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T1 - Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption

AU - Herrera, Iliana

AU - Cisneros, José

AU - Maldonado, Mariel

AU - Ramírez, Remedios

AU - Ortiz-Quintero, Blanca

AU - Anso, Elena

AU - Chandel, Navdeep

AU - Selman, Moisés

AU - Pardo, Annie

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AB - Background: In IPF MMP-1 is up-regulated and expressed in alveolar epithelial cells. Result: Transfection of MMP-1 in MLE cells increased proliferation/migration, protected from apoptosis, repressed oxygen consumption ratio and ROS production, and stimulated HIF-1. Conclusion: MMP-1 inhibits mitochondrial function and contributes to a proliferative/migratory and anti-apoptotic phenotype. Significance: MMP-1 promotes the Warburg effect characterized by increased aerobic glycolysis and HIF-1 during normoxia.

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