MCU meets cardiolipin: Calcium and disease follow form

Priscilla See Wai Yeung, Murali Prakriya*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

Abstract

Cardiolipin (CL) is a cone-shaped lipid found nearly exclusively in the inner mitochondrial membrane of animal cells. Disruption of CL synthesis leads to abnormalities in mitochondrial shape and function, but the underlying causes are incompletely understood. We highlight a new study that reveals that the activity of the mitochondrial calcium uniporter (MCU) is regulated by CL, advancing our understanding of the mechanisms of CL-linked human disease.

Original languageEnglish (US)
Article number102287
JournalCell Calcium
Volume92
DOIs
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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