MDA5 and LGP2: Accomplices and antagonists of antiviral signal transduction

Kenny R. Rodriguez, Annie M. Bruns, Curt M. Horvath*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

77 Scopus citations


Mammalian cells have the ability to recognize virus infection and mount a powerful antiviral transcriptional response that provides an initial barrier to replication and impacts both innate and adaptive immune responses. Retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) proteins mediate intracellular virus recognition and are activated by viral RNA ligands to induce antiviral signal transduction. While the mechanisms of RIG-I regulation are already well understood, less is known about the more enigmatic melanoma differentiation-associated 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2). Emerging evidence suggests that these two RLRs are intimately associated as both accomplices and antagonists of antiviral signal transduction.

Original languageEnglish (US)
Pages (from-to)8194-8200
Number of pages7
JournalJournal of virology
Issue number15
StatePublished - 2014

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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