TY - JOUR
T1 - Meaningful change thresholds for patient-reported outcomes measurement information system (PROMIS) fatigue and pain interference scores in patients with rheumatoid arthritis
AU - Beaumont, Jennifer L.
AU - Davis, Elizabeth S.
AU - Curtis, Jeffrey R.
AU - Cella, David
AU - Yun, Huifeng
N1 - Publisher Copyright:
© 2021 The Journal of Rheumatology.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Objective. We estimated meaningful change thresholds (MCTs) for Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue and Pain Interference in rheumatoid arthritis (RA). Methods. The responsiveness of several patient-reported outcomes (PROs) was assessed among 521 patients with RA in the Arthritis, Rheumatism, and Aging Medical Information Systems (ARAMIS) cohort. PROMIS Fatigue (7-item) and Pain Interference (6-item) short form instruments were administered at baseline, 6 months, and 12 months. Self-reported retrospective changes over the previous 6 months (a lot better/ worse, a little better/worse, stayed the same) were obtained at 6 and 12 months’ follow-up. We estimated MCTs using the mean change in PROMIS scores for patients who rated their change “a little better” or “a little worse.” Results. Baseline fatigue and pain interference scores were near normal (median 54 and 56, respectively). At 6 months, 7.9% of patients reported their fatigue was a little better compared to baseline (mean change [SD]: –2.6 [4.8]) and 22.8% a little worse (1.7 [5.6]). Pain was a little better for 11.5% of patients (–1.9 [6.1]) and a little worse for 24.2% of patients (0.6 [5.7]). At 12 months, results were similar. Thus, the MCT range was 1–2 points for both fatigue and pain interference. Correlations between change scores and retrospective ratings were low (0.13–0.29), indicating possible underestimation of MCT. Conclusion. The group-level MCT for PROMIS Fatigue and Pain Interference is roughly 2–3 points and corresponds to a small effect size, which is consistent with earlier work demonstrating an MCT of 2 points for PROMIS Physical Functioning.
AB - Objective. We estimated meaningful change thresholds (MCTs) for Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue and Pain Interference in rheumatoid arthritis (RA). Methods. The responsiveness of several patient-reported outcomes (PROs) was assessed among 521 patients with RA in the Arthritis, Rheumatism, and Aging Medical Information Systems (ARAMIS) cohort. PROMIS Fatigue (7-item) and Pain Interference (6-item) short form instruments were administered at baseline, 6 months, and 12 months. Self-reported retrospective changes over the previous 6 months (a lot better/ worse, a little better/worse, stayed the same) were obtained at 6 and 12 months’ follow-up. We estimated MCTs using the mean change in PROMIS scores for patients who rated their change “a little better” or “a little worse.” Results. Baseline fatigue and pain interference scores were near normal (median 54 and 56, respectively). At 6 months, 7.9% of patients reported their fatigue was a little better compared to baseline (mean change [SD]: –2.6 [4.8]) and 22.8% a little worse (1.7 [5.6]). Pain was a little better for 11.5% of patients (–1.9 [6.1]) and a little worse for 24.2% of patients (0.6 [5.7]). At 12 months, results were similar. Thus, the MCT range was 1–2 points for both fatigue and pain interference. Correlations between change scores and retrospective ratings were low (0.13–0.29), indicating possible underestimation of MCT. Conclusion. The group-level MCT for PROMIS Fatigue and Pain Interference is roughly 2–3 points and corresponds to a small effect size, which is consistent with earlier work demonstrating an MCT of 2 points for PROMIS Physical Functioning.
KW - Fatigue
KW - Pain
KW - Rheumatoid arthritis
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U2 - 10.3899/jrheum.200990
DO - 10.3899/jrheum.200990
M3 - Article
C2 - 33722955
AN - SCOPUS:85110335695
VL - 48
SP - 1239
EP - 1242
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 8
ER -