Measles IgM response during reinfection of previously vaccinated children

Calvin C. Linnemann*, Marion E. Hegg, Thomas C. Rotte, John P. Phair, Gilbert M. Schiff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Measles IgM antibody was found in the convalescent sera from five of seven childrenwith a primary measles infection, but in only two of seven previously vaccinated children with clinical measles, and in none of seven previously vaccinated children who were revaccinated with attenuated measles virus. Since specific IgM antibody is characteristic of a primary immune response to measles virus, the absence of IgM indicates that some children are experiencing a reinfection despite a primary antigenic stimulus by the vaccine.

Original languageEnglish (US)
Pages (from-to)798-801
Number of pages4
JournalThe Journal of pediatrics
Volume82
Issue number5
DOIs
StatePublished - May 1973

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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