Measles IgM response during reinfection of previously vaccinated children

Calvin C. Linnemann; Marion E. Hegg; Thomas C. Rotte; John P. Phair; Gilbert M. Schiff

doi:10.1016/S0022-3476(73)80069-1

Measles IgM response during reinfection of previously vaccinated children

Calvin C. Linnemann^*, Marion E. Hegg, Thomas C. Rotte, John P. Phair, Gilbert M. Schiff

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Measles IgM antibody was found in the convalescent sera from five of seven childrenwith a primary measles infection, but in only two of seven previously vaccinated children with clinical measles, and in none of seven previously vaccinated children who were revaccinated with attenuated measles virus. Since specific IgM antibody is characteristic of a primary immune response to measles virus, the absence of IgM indicates that some children are experiencing a reinfection despite a primary antigenic stimulus by the vaccine.

Original language	English (US)
Pages (from-to)	798-801
Number of pages	4
Journal	The Journal of pediatrics
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(73)80069-1
State	Published - May 1973

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0022-3476(73)80069-1

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title = "Measles IgM response during reinfection of previously vaccinated children",

abstract = "Measles IgM antibody was found in the convalescent sera from five of seven childrenwith a primary measles infection, but in only two of seven previously vaccinated children with clinical measles, and in none of seven previously vaccinated children who were revaccinated with attenuated measles virus. Since specific IgM antibody is characteristic of a primary immune response to measles virus, the absence of IgM indicates that some children are experiencing a reinfection despite a primary antigenic stimulus by the vaccine.",

author = "Linnemann, {Calvin C.} and Hegg, {Marion E.} and Rotte, {Thomas C.} and Phair, {John P.} and Schiff, {Gilbert M.}",

note = "Funding Information: Supported in part by United States Public Health Service Research Grant No. R01 CC00524.",

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doi = "10.1016/S0022-3476(73)80069-1",

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AU - Linnemann, Calvin C.

AU - Hegg, Marion E.

AU - Rotte, Thomas C.

AU - Phair, John P.

AU - Schiff, Gilbert M.

N1 - Funding Information: Supported in part by United States Public Health Service Research Grant No. R01 CC00524.

PY - 1973/5

Y1 - 1973/5

N2 - Measles IgM antibody was found in the convalescent sera from five of seven childrenwith a primary measles infection, but in only two of seven previously vaccinated children with clinical measles, and in none of seven previously vaccinated children who were revaccinated with attenuated measles virus. Since specific IgM antibody is characteristic of a primary immune response to measles virus, the absence of IgM indicates that some children are experiencing a reinfection despite a primary antigenic stimulus by the vaccine.

AB - Measles IgM antibody was found in the convalescent sera from five of seven childrenwith a primary measles infection, but in only two of seven previously vaccinated children with clinical measles, and in none of seven previously vaccinated children who were revaccinated with attenuated measles virus. Since specific IgM antibody is characteristic of a primary immune response to measles virus, the absence of IgM indicates that some children are experiencing a reinfection despite a primary antigenic stimulus by the vaccine.

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Measles IgM response during reinfection of previously vaccinated children

Abstract

ASJC Scopus subject areas

UN SDGs

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