Measurement properties of 4 patient-reported outcome measures to assess sleep disturbance in adults with atopic dermatitis

Donald K. Lei, Muhammad Yousaf, Sherief R. Janmohamed, Paras P. Vakharia, Rishi Chopra, Rajeev Chavda, Sylvie Gabriel, Ryan Sacotte, Kevin R. Patel, Vivek Singam, Robert Kantor, Derek Y. Hsu, David Cella, Jonathan I. Silverberg*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background The ideal patient-reported outcome measure to assess sleep disturbance in atopic dermatitis (AD) has not been determined. Objective We sought to determine the measurement properties of the Patient-Reported Outcomes Measurement Information System® (PROMIS®) Itch Questionnaire Mood and Sleep (PIQ-MS), Sleep Disturbance (SD), Sleep-Related Impairment (SRI), and Epworth Sleepiness Scale (ESS) in adults with AD. Methods A prospective dermatology practice-based study was performed using questionnaires and evaluation by a dermatologist (n=611). Results PIQ-MS, PROMIS SD, SRI, and ESS had good convergent validity with intensity and frequency of sleep disturbance, Patient-Oriented Eczema Measure, Eczema Area and Severity Index, total and objective-Scoring AD, Numerical Rating Scale of worst-itch and average-itch, and Dermatology Life Quality Index. PIQ-MS had significantly better correlations with other severity measures than the other sleep measures (Fisher z-scores, P≤0.007). PIQ-MS, and to lesser extent PROMIS SD, PROMIS SRI and ESS had good discriminant validity. All four sleep assessments showed fair responsiveness to change of severity of sleep-disturbance, AD and itch. PIQ-MS had the best reliability. PIQ-MS, PROMIS SD, SRI and ESS showed good internal consistency and were feasible for use in clinical practice. Conclusions PIQ-MS, followed by PROMIS SD, had the best construct validity and reliability in adult AD.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalDermatitis
Volume31
Issue number5
DOIs
StatePublished - Sep 1 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

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    Lei, D. K., Yousaf, M., Janmohamed, S. R., Vakharia, P. P., Chopra, R., Chavda, R., Gabriel, S., Sacotte, R., Patel, K. R., Singam, V., Kantor, R., Hsu, D. Y., Cella, D., & Silverberg, J. I. (2020). Measurement properties of 4 patient-reported outcome measures to assess sleep disturbance in adults with atopic dermatitis. Dermatitis, 31(5), 321-327. https://doi.org/10.1097/DER.0000000000000625