TY - JOUR
T1 - Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients with Atopic Dermatitis
AU - Silverberg, Jonathan I
AU - Lee, Brad
AU - Lei, Donald
AU - Yousaf, Muhammad
AU - Janmohamed, Sherief R.
AU - Vakharia, Paras P.
AU - Chopra, Rishi
AU - Chavda, Rajeev
AU - Gabriel, Sylvie
AU - Patel, Kevin R.
AU - Singam, Vivek
AU - Kantor, Robert
AU - Hsu, Derek Y.
N1 - Funding Information:
This publication was made possible with support from the Agency for Healthcare Research and Quality (grant K12 HS023011), the Dermatology Foundation, and an unrestricted research grant from Galderma.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2021
Y1 - 2021
N2 - Background Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms. Objective We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted. Results PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82). Conclusions PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.
AB - Background Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms. Objective We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted. Results PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82). Conclusions PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.
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U2 - 10.1097/DER.0000000000000653
DO - 10.1097/DER.0000000000000653
M3 - Article
C2 - 33273219
AN - SCOPUS:85102782554
SN - 1710-3568
VL - 32
SP - 225
EP - 231
JO - Dermatitis
JF - Dermatitis
IS - 4
ER -