Measurement properties of the Patient-Reported Outcomes Measurement Information System Itch Questionnaire item banks in adults with atopic dermatitis

Jonathan I. Silverberg*, Jin Shei Lai, Paras P. Vakharia, Kevin Patel, Vivek Singam, Rishi Chopra, Ryan Sacotte, Neha Patel, Supriya Rastogi, Robert Kantor, Derek Y. Hsu, David Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. Objective: To validate PIQ short forms in adults with AD. Methods: Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermatology practice setting. Results: PIQ items had good content validity. PIQ item bank T-scores strongly correlated with each other, moderately correlated with numeric and verbal rating scales for worst or average itch and with itch frequency, moderately to strongly correlated with patient-oriented eczema measure, and weakly to moderately correlated with the Eczema Area and Severity Index and Objective-Scoring AD (Spearman correlations, P < .0001). There were significant and stepwise increases of T-scores for all item banks with increasing patient-reported global severity (Wilcoxon rank sum test, P < .0001). However, there was limited ability to discriminate between the lowest or highest 2 levels of AD or itch severity. Item banks showed good internal consistency (Cronbach α, 0.91-0.95). No differential item functioning was identified by age, sex, race/ethnicity, or educational level. There were floor effects for total scores, particularly in almost clear/mild AD or itch. Limitations: Single-center study. Conclusions: PIQ item bank short forms showed good content and construct validity and are feasible for potential use in clinical trials and practice.

Original languageEnglish (US)
Pages (from-to)1174-1180
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume82
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • atopic dermatitis
  • burden
  • eczema
  • itch
  • patient-reported outcomes
  • pruritus
  • quality of life
  • severity

ASJC Scopus subject areas

  • Dermatology

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