Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography

Siyu Chen, Ji Yi, Sam Inayat, Wenzhong Liu, Jianhua Cang, Hao F. Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3881-3884
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • Medicine(all)

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    Chen, S., Yi, J., Inayat, S., Liu, W., Cang, J., & Zhang, H. F. (2014). Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 3881-3884). [6944471] (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6944471