Abstract
We present a novel instrument for imaging the angular distributions of light backscattered by biological cells and tissues. The intensities in different regions of the image are due to scatterers of different sizes. We exploit this to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from subcellular structure in both normal and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.
Original language | English (US) |
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Pages (from-to) | 887-893 |
Number of pages | 7 |
Journal | IEEE Journal on Selected Topics in Quantum Electronics |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2001 |
Funding
Manuscript received August 10, 2001; revised October 30, 2001. This work was supported by NIH Grant P41-RR02594 and by NIH Grant R01-CA53717. V. Backman is with the Biomedical Engineering Department, Northwestern University, Evanston, IL 60208 USA. V. Gopal, M. Kalashnikov, R. Gurjar, A. Wax, I. Georgakoudi, M. Mueller, C. W. Boone, R. R. Dasari, and M. S. Feld are with the G.R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139 USA. K. Badizadegan is with the Department of Pathology, Children’s Hospital, Harvard Medical School, Boston, MA 02115 USA. Publisher Item Identifier S 1077-260X(01)11252-9.
Keywords
- Cancer diagnosis
- Chromatin
- Fractal
- Light scattering
- Spectroscopy
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering