Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy

Vadim Backman; Venkatesh Gopal; Maxim Kalashnikov; Kamran Badizadegan; Rajan Gurjar; Adam Wax; Irene Georgakoudi; Marcus Mueller; Charles W. Boone; Ramachandra R. Dasari; Michael S. Feld

Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy

Vadim Backman^*, Venkatesh Gopal, Maxim Kalashnikov, Kamran Badizadegan, Rajan Gurjar, Adam Wax, Irene Georgakoudi, Marcus Mueller, Charles W. Boone, Ramachandra R. Dasari, Michael S. Feld

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present an innovative technique for simultaneous measurement of the angular and spectral distributions of light backscattered by biological cells and tissues. The intensities of light scattered to different angular regions are due to scatterers of different sizes. We exploit this fact to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from sub-cellular structure in normal, precancerous, and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.

Original language	English (US)
Title of host publication	Biomedical Topical Meeting, BIOMED 2002
Publisher	Optica Publishing Group (formerly OSA)
Pages	661-663
Number of pages	3
ISBN (Electronic)	1557527024
State	Published - 2002
Event	Biomedical Topical Meeting, BIOMED 2002 - Miami Beach, United States Duration: Apr 7 2002 → Apr 10 2002

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Electronic)	2162-2701

Conference

Conference	Biomedical Topical Meeting, BIOMED 2002
Country/Territory	United States
City	Miami Beach
Period	4/7/02 → 4/10/02

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Backman, V., Gopal, V., Kalashnikov, M., Badizadegan, K., Gurjar, R., Wax, A., Georgakoudi, I., Mueller, M., Boone, C. W., Dasari, R. R., & Feld, M. S. (2002). Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy. In Biomedical Topical Meeting, BIOMED 2002 (pp. 661-663). (Optics InfoBase Conference Papers). Optica Publishing Group (formerly OSA).

@inproceedings{1e4877db1ae34d8a9c9fc8a60782e5b9,

title = "Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy",

abstract = "We present an innovative technique for simultaneous measurement of the angular and spectral distributions of light backscattered by biological cells and tissues. The intensities of light scattered to different angular regions are due to scatterers of different sizes. We exploit this fact to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from sub-cellular structure in normal, precancerous, and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.",

author = "Vadim Backman and Venkatesh Gopal and Maxim Kalashnikov and Kamran Badizadegan and Rajan Gurjar and Adam Wax and Irene Georgakoudi and Marcus Mueller and Boone, {Charles W.} and Dasari, {Ramachandra R.} and Feld, {Michael S.}",

note = "Publisher Copyright: {\textcopyright} 2000 Optical Society of America.; Biomedical Topical Meeting, BIOMED 2002 ; Conference date: 07-04-2002 Through 10-04-2002",

year = "2002",

language = "English (US)",

series = "Optics InfoBase Conference Papers",

publisher = "Optica Publishing Group (formerly OSA)",

pages = "661--663",

booktitle = "Biomedical Topical Meeting, BIOMED 2002",

}

Backman, V, Gopal, V, Kalashnikov, M, Badizadegan, K, Gurjar, R, Wax, A, Georgakoudi, I, Mueller, M, Boone, CW, Dasari, RR & Feld, MS 2002, Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy. in Biomedical Topical Meeting, BIOMED 2002. Optics InfoBase Conference Papers, Optica Publishing Group (formerly OSA), pp. 661-663, Biomedical Topical Meeting, BIOMED 2002, Miami Beach, United States, 4/7/02.

Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy. / Backman, Vadim; Gopal, Venkatesh; Kalashnikov, Maxim et al.
Biomedical Topical Meeting, BIOMED 2002. Optica Publishing Group (formerly OSA), 2002. p. 661-663 (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy

AU - Backman, Vadim

AU - Gopal, Venkatesh

AU - Kalashnikov, Maxim

AU - Badizadegan, Kamran

AU - Gurjar, Rajan

AU - Wax, Adam

AU - Georgakoudi, Irene

AU - Mueller, Marcus

AU - Boone, Charles W.

AU - Dasari, Ramachandra R.

AU - Feld, Michael S.

PY - 2002

Y1 - 2002

N2 - We present an innovative technique for simultaneous measurement of the angular and spectral distributions of light backscattered by biological cells and tissues. The intensities of light scattered to different angular regions are due to scatterers of different sizes. We exploit this fact to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from sub-cellular structure in normal, precancerous, and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.

AB - We present an innovative technique for simultaneous measurement of the angular and spectral distributions of light backscattered by biological cells and tissues. The intensities of light scattered to different angular regions are due to scatterers of different sizes. We exploit this fact to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from sub-cellular structure in normal, precancerous, and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.

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UR - http://www.scopus.com/inward/citedby.url?scp=85135959061&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85135959061

T3 - Optics InfoBase Conference Papers

SP - 661

EP - 663

BT - Biomedical Topical Meeting, BIOMED 2002

PB - Optica Publishing Group (formerly OSA)

T2 - Biomedical Topical Meeting, BIOMED 2002

Y2 - 7 April 2002 through 10 April 2002

ER -

Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy

Abstract

Publication series

Conference

ASJC Scopus subject areas

UN SDGs

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