Measuring Cellular Structure at Submicron Scale with Scattering Angle Sensitive Light Scattering Spectroscopy

Vadim Backman*, Venkatesh Gopal, Maxim Kalashnikov, Kamran Badizadegan, Rajan Gurjar, Adam Wax, Irene Georgakoudi, Marcus Mueller, Charles W. Boone, Ramachandra R. Dasari, Michael S. Feld

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We present an innovative technique for simultaneous measurement of the angular and spectral distributions of light backscattered by biological cells and tissues. The intensities of light scattered to different angular regions are due to scatterers of different sizes. We exploit this fact to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from sub-cellular structure in normal, precancerous, and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.

Original languageEnglish (US)
Title of host publicationBiomedical Topical Meeting, BIOMED 2002
PublisherOptica Publishing Group (formerly OSA)
Number of pages3
ISBN (Electronic)1557527024
StatePublished - 2002
EventBiomedical Topical Meeting, BIOMED 2002 - Miami Beach, United States
Duration: Apr 7 2002Apr 10 2002

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceBiomedical Topical Meeting, BIOMED 2002
Country/TerritoryUnited States
CityMiami Beach

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


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