Measuring EGJ opening patterns using high resolution intraluminal impedance

John E. Pandolfino*, G. Shi, Q. Zhang, S. Ghosh, J. G. Brasseur, P. J. Kahrilas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The aim of this study was to adapt impedance methodology to study esophagogastric junction (EGJ) sphincter opening and compare opening patterns of the EGJ during deglutitive LES relaxation (dLESR) and transient LES relaxation (dLESR). We studied eight healthy subjects with a novel 12-lumen combined impedance/manometry catheter, the main element of which was a 6 cm sleeve sensor with six side hole sensors and six impedance zings spaced at 1 cm increments along its length. Subjects underwent an air infusion protocol after standard assessment and data tracings and isocontour plots were analysed to assess opening characteristics of the EGJ during dLESRs and tLESRs. Our results revealed that during dLESR the opening pattern was top to bottom, occurred in 0-2.7 s and in 29 of 35 (83%) cases the leading edge of the bolus was liquid. Opening during tLESR began between -7.8 and +8.6 s relative to the onset of nadir LES relaxation. The opening pattern during tLESR was bottom to top, occurred in 0-7.7 s, and in 22 of 29 (76%) the leading edge was liquid. These results support that impedance monitoring can be adapted to identify sphincter opening, to distinguish sphincter opening from sphincter relaxation, and to determine luminal contents during the opening period.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalNeurogastroenterology and Motility
Issue number2
StatePublished - Apr 2005


  • Esophagogastric Junction
  • Intraluminal impedance
  • Transient LES relaxations

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


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