Measuring health-related quality of life in leukemia: The functional assessment of cancer therapy - Leukemia (FACT-Leu) questionnaire

David Cella*, Sally E. Jensen, Kimberly Webster, Du Hongyan, Jin Shei Lai, Steven Rosen, Martin S. Tallman, Susan Yount

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Objective: Develop and validate a health-related quality-of-life (measure for patients with acute and chronic leukemia. Methods: The study consisted of two phases: scale construction and scale validation. For the item-generation phase, a summary of the literature combined with qualitative results from item-generation interviews with 29 acute or chronic leukemia patients and 16 health care providers yielded an initial item pool reflecting leukemia-specific concerns and symptoms. Items underwent iterations of review and reduction according to defined retention criteria to support content validity, as defined by priority concerns of patients. Seventeen final leukemia-specific items were combined with the Functional Assessment of Cancer Therapy-General to create the FACT-Leukemia (FACT-Leu) scale. For the validation phase, 79 individuals with acute or chronic leukemia completed questionnaires at three time points. Results: All FACT-Leu subscale and aggregated scores showed high internal consistency (αs ranging from 0.75 to 0.96). Test-retest reliability was adequate for all subscales (intraclass correlation range 0.765-0.890). The FACT-Leu scale demonstrated good convergent validity, with significant correlations with quality-of-life criteria and performance status, in the expected direction. FACT-Leu subscale scores were significantly different among the three performance status change groups, suggesting good responsiveness to change. Conclusions: The FACT-Leu scale is a valid, reliable, and efficient measure of leukemia-specific health-related quality of life for acute and chronic disease.

Original languageEnglish (US)
Pages (from-to)1051-1058
Number of pages8
JournalValue in Health
Issue number8
StatePublished - Dec 2012


  • acute leukemia
  • chronic leukemia
  • health-related quality of life
  • patient-reported outcomes

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health


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