Mechanical and cold allodynia in a rat spinal cord contusion model

Young Wook Yoon; Hongxin Dong; Joop J A Arends; Mark F. Jacquin

doi:10.1080/0899022042000201272

Mechanical and cold allodynia in a rat spinal cord contusion model

Young Wook Yoon, Hongxin Dong, Joop J A Arends, Mark F. Jacquin^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.

Original language	English (US)
Pages (from-to)	25-31
Number of pages	7
Journal	Somatosensory and Motor Research
Volume	21
Issue number	1
DOIs	https://doi.org/10.1080/0899022042000201272
State	Published - 2004

Keywords

Allodynia
Hindpaw
Injury
Neuropathic pain
Spinal cord
Von Frey

ASJC Scopus subject areas

Physiology
Sensory Systems

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10.1080/0899022042000201272

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title = "Mechanical and cold allodynia in a rat spinal cord contusion model",

abstract = "This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.",

keywords = "Allodynia, Hindpaw, Injury, Neuropathic pain, Spinal cord, Von Frey",

author = "Yoon, {Young Wook} and Hongxin Dong and Arends, {Joop J A} and Jacquin, {Mark F.}",

note = "Funding Information: The authors would like to thank Dr Michael Howard for his comments on the manuscript. This work was supported by NIH grant NS39577 to M.F.J. Y.W. Yoon was supported in part by the Kil Chung Hee Fellowship Fund.",

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AU - Arends, Joop J A

AU - Jacquin, Mark F.

N1 - Funding Information: The authors would like to thank Dr Michael Howard for his comments on the manuscript. This work was supported by NIH grant NS39577 to M.F.J. Y.W. Yoon was supported in part by the Kil Chung Hee Fellowship Fund.

PY - 2004

Y1 - 2004

N2 - This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.

AB - This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.

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KW - Injury

KW - Neuropathic pain

KW - Spinal cord

KW - Von Frey

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Mechanical and cold allodynia in a rat spinal cord contusion model

Abstract

Keywords

ASJC Scopus subject areas

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