Mechanical and cold allodynia in a rat spinal cord contusion model

Young Wook Yoon, Hongxin Dong, Joop J A Arends, Mark F. Jacquin*

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalSomatosensory and Motor Research
Volume21
Issue number1
DOIs
StatePublished - Apr 26 2004

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Keywords

  • Allodynia
  • Hindpaw
  • Injury
  • Neuropathic pain
  • Spinal cord
  • Von Frey

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

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