Mechanical Characterization of Biofilms by Optical Coherence Elastography (OCE) Measurements of Elastic Waves

Hong Cin Liou, Fabrizio Sabba, George Wells, Oluwaseyi Balogun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biofilms are biological materials composed of microbial communities encased in a self-produced extracellular polymeric substance (EPS). The viscoelastic properties of biofilms are related to the cross-link density in the EPS and ultimately the cohesiveness of biofilms. Accurate measurement of biofilm viscoelastic properties at the mesoscale remains a challenge. Rheological measurements, although being more common, provide only global properties, do not permit in-situ characterization, and are not amenable to complex sample geometries. To address these challenges, our work seeks to develop a nondestructive framework for characterizing biofilm viscoelastic properties using elastic wave propagation measured by the optical coherence elastography technique. The framework holds great potential to elucidate spatially varying mechanical properties and their correlation with sample morphology and composition.

Original languageEnglish (US)
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages2194-2197
Number of pages4
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: Oct 6 2019Oct 9 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period10/6/1910/9/19

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Keywords

  • biofilm
  • elastic wave propagation
  • nondestructive viscoelastic characterization
  • optical coherence elastography

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Liou, H. C., Sabba, F., Wells, G., & Balogun, O. (2019). Mechanical Characterization of Biofilms by Optical Coherence Elastography (OCE) Measurements of Elastic Waves. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 2194-2197). [8925714] (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2019.8925714