Mechanism and regulation of transcriptional elongation and termination by RNA polymerase II

Ali Shilatifard, Joan Weliky Conaway, Ronald C. Conaway*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Over the past year, key advances in several areas of research on the structure and function of the RNA polymerase (pol II) elongation complex have shed considerable light on the mechanisms governing the elongation stage of eukaryotic mRNA synthesis. Novel features of the regulation of elongation by DNA and RNA binding transcriptional activators have been brought to light; the mechanisms of action of elongation factors that suppress pausing and premature arrest by transcribing pol II have been defined in greater detail; and novel elongation factors implicated in human disease have been identified and characterized.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume7
Issue number2
DOIs
StatePublished - Apr 1997

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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