Abstract
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor in human adults. Myeloid-lineage cells, including macrophages, microglia, myeloid-derived suppressor cells (MDSCs), and neutrophils, are the most frequent types of cell in the GBM tumor microenvironment (TME) that contribute to tumor progression. Emerging experimental evidence indicates that symbiotic interactions between cancer cells and myeloid cells are critical for tumor growth and immunotherapy resistance in GBM. In this review, we discuss the molecular mechanisms whereby cancer cells shape a myeloid cell-mediated immunosuppressive TME and, reciprocally, how such myeloid cells affect tumor progression and immunotherapy efficiency in GBM. Moreover, we highlight tumor-T cell symbiosis and summarize immunotherapeutic strategies intercepting this co-dependency in GBM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 839-854 |
| Number of pages | 16 |
| Journal | Trends in Cancer |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2022 |
Funding
This work was supported by National Institutes of Health ( NIH ) R00 CA240896 (P.C.), DoD Career Development Award W81XWH-21-1-0380 (P.C.), Cancer Research Foundation Young Investigator Award (P.C.), Lynn Sage Scholar Award (P.C.), American Cancer Society Institutional Research Grant IRG-21-144-27 (P.C.), philanthropic donation from Mindy Jacobson and the Bill Bass Foundation (P.C.), Northwestern University start-up funds (P.C.), and the Robert H. Lurie Comprehensive Cancer Center (P.C.).
Keywords
- MDSCs
- glioblastoma
- immunotherapy
- macrophages
- microglia
- symbiosis
ASJC Scopus subject areas
- Oncology
- Cancer Research
