Mechanism of the involvement of monoamine oxidase in the regulation of (Na+ + K+)-ATPase in rat brain

Chandra Shekhar K Mayanil, Najma Z. Baquer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Increasing concentrations of dopamine fail to give a biphasic response to (Na+ + K+)-ATPase activity in various subcellular fractions of rat brain preincubated with monoamine oxidase inhibitors, viz. 1·10-4 M clorgyline and 1·10-4 M deprenyl. The product of the monoamine-oxidase-catalysed reaction with dopamine as substrate is 3-methoxy-4-hydroxyphenylacetaldehyde. An analogue of this product is 3-methoxy-4-hydroxybenzaldehyde. This analogue, when incubated with the subcellular fractions which had been preincubated with monoamine oxidase inhibitors and dopamine, gave a more pronounced biphasic response to (Na+ + K+)-ATPase activity than that observed in the fractions incubated with dopamine alone.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalBBA - General Subjects
Issue number2
StatePublished - May 25 1983


  • (Na + K)-ATPase
  • (Rat Brain)
  • Dopamine
  • Monoamine oxidase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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