Mechanism of the involvement of monoamine oxidase in the regulation of (Na+ + K+)-ATPase in rat brain

Chandra Shekhar K Mayanil; Najma Z. Baquer

doi:10.1016/0304-4165(83)90102-2

Mechanism of the involvement of monoamine oxidase in the regulation of (Na⁺ + K⁺)-ATPase in rat brain

Chandra Shekhar K Mayanil, Najma Z. Baquer^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Increasing concentrations of dopamine fail to give a biphasic response to (Na⁺ + K⁺)-ATPase activity in various subcellular fractions of rat brain preincubated with monoamine oxidase inhibitors, viz. 1·10^-4 M clorgyline and 1·10^-4 M deprenyl. The product of the monoamine-oxidase-catalysed reaction with dopamine as substrate is 3-methoxy-4-hydroxyphenylacetaldehyde. An analogue of this product is 3-methoxy-4-hydroxybenzaldehyde. This analogue, when incubated with the subcellular fractions which had been preincubated with monoamine oxidase inhibitors and dopamine, gave a more pronounced biphasic response to (Na⁺ + K⁺)-ATPase activity than that observed in the fractions incubated with dopamine alone.

Original language	English (US)
Pages (from-to)	151-155
Number of pages	5
Journal	BBA - General Subjects
Volume	757
Issue number	2
DOIs	https://doi.org/10.1016/0304-4165(83)90102-2
State	Published - May 25 1983

Keywords

(Na + K)-ATPase
(Rat Brain)
Dopamine
Monoamine oxidase

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

Access to Document

10.1016/0304-4165(83)90102-2

Cite this

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title = "Mechanism of the involvement of monoamine oxidase in the regulation of (Na+ + K+)-ATPase in rat brain",

abstract = "Increasing concentrations of dopamine fail to give a biphasic response to (Na+ + K+)-ATPase activity in various subcellular fractions of rat brain preincubated with monoamine oxidase inhibitors, viz. 1·10-4 M clorgyline and 1·10-4 M deprenyl. The product of the monoamine-oxidase-catalysed reaction with dopamine as substrate is 3-methoxy-4-hydroxyphenylacetaldehyde. An analogue of this product is 3-methoxy-4-hydroxybenzaldehyde. This analogue, when incubated with the subcellular fractions which had been preincubated with monoamine oxidase inhibitors and dopamine, gave a more pronounced biphasic response to (Na+ + K+)-ATPase activity than that observed in the fractions incubated with dopamine alone.",

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N2 - Increasing concentrations of dopamine fail to give a biphasic response to (Na+ + K+)-ATPase activity in various subcellular fractions of rat brain preincubated with monoamine oxidase inhibitors, viz. 1·10-4 M clorgyline and 1·10-4 M deprenyl. The product of the monoamine-oxidase-catalysed reaction with dopamine as substrate is 3-methoxy-4-hydroxyphenylacetaldehyde. An analogue of this product is 3-methoxy-4-hydroxybenzaldehyde. This analogue, when incubated with the subcellular fractions which had been preincubated with monoamine oxidase inhibitors and dopamine, gave a more pronounced biphasic response to (Na+ + K+)-ATPase activity than that observed in the fractions incubated with dopamine alone.

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