Mechanisms of Allergic Sensitization to Foods: Bypassing Immune Tolerance Pathways

M. Cecilia Berin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The default response of the mucosal immune system to antigens derived from food is one of active immune tolerance carried out by regulatory T cells and induced by dendritic cells residing in the intestinal mucosa. This tolerance response must be inhibited or bypassed to generate allergic sensitization in experimental food allergy and this has been achieved by 3 main approaches: genetic modifications, experimental adjuvants, and bypassing oral tolerance by administering the antigen through alternative routes. This article discusses the implications of these approaches for understanding the mechanisms of sensitization to food allergens in human disease.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalImmunology and Allergy Clinics of North America
Issue number1
StatePublished - Feb 2012


  • Adjuvant
  • Dendritic cell
  • Epicutaneous
  • Innate immunity
  • IT
  • Oral tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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