Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

Marcus E. Peter; Peter H. Krammer

doi:10.1016/S0952-7915(98)80222-7

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

Marcus E. Peter^*, Peter H. Krammer

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

422 Scopus citations

Abstract

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

Original language	English (US)
Pages (from-to)	545-551
Number of pages	7
Journal	Current Opinion in Immunology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0952-7915(98)80222-7
State	Published - Oct 1998

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(98)80222-7

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title = "Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis",

abstract = "This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.",

author = "Peter, {Marcus E.} and Krammer, {Peter H.}",

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AU - Krammer, Peter H.

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AB - This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

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Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

Abstract

ASJC Scopus subject areas

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