Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

Marcus E. Peter*, Peter H. Krammer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

401 Scopus citations


This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalCurrent Opinion in Immunology
Issue number5
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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