Mechanisms of disease: Vitamin D and inflammatory bowel disease

Wee Chian Lim, Stephen B. Hanauer*, Yan Chun Li

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations


Until recently, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) - the active form of vitamin D - was thought to function primarily as a regulator of calcium and phosphate metabolism. More diverse functionality was indicated by the discovery of the vitamin D receptor in tissues that are not involved in calcium and phosphate homeostasis. Detection of the vitamin D receptor in monocytes and activated T cells has sparked interest in the immunomodulatory properties of vitamin D. Here, we review the role of vitamin D in regulation of the immune system, and evidence for its involvement in the pathogenesis of inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)308-315
Number of pages8
JournalNature Clinical Practice Gastroenterology and Hepatology
Issue number7
StatePublished - Jul 1 2005


  • Crohn's disease
  • Inflammation
  • Inflammatory bowel disease
  • Ulcerative colitis
  • Vitamin D

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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