Mechanisms of immune evasion by gliomas

Cleo E. Rolle, Sadhak Sengupta, MacIej S. Lesniak*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

70 Scopus citations

Abstract

A major contributing factor to glioma development and progression is its ability to evade the immune system. This chapter will explore the mechanisms utilized by glioma to mediate immunosuppression and immune evasion. These include intrinsic mechanisms linked to its location within the brain and interactions between glioma cells and immune cells. Lack of recruitment of naïve effector immune cells perhaps accounts for most of the immune suppression mediated by these tumor cells. This is enhanced by increased recruitment of microglia which resemble immature antigen presenting cells that are unable to support T-cell mediated immunity. Furthermore, secreted factors like TGF-β, COX-2 and IL-10, altered costimulatory molecules and inhibition of STAT-3 all contribute to the recruitment and expansion of regulatory T cells, which further modulate the immunosuppressive environment of glioma. In light of these findings, multiple immunotherapeutic treatment modalities are currently being explored.

Original languageEnglish (US)
Title of host publicationGlioma
Subtitle of host publicationImmunotherapeutic Approaches
EditorsRyuya Yamanaka
Pages53-76
Number of pages24
DOIs
StatePublished - Jul 3 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume746
ISSN (Print)0065-2598

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rolle, C. E., Sengupta, S., & Lesniak, M. S. (2012). Mechanisms of immune evasion by gliomas. In R. Yamanaka (Ed.), Glioma: Immunotherapeutic Approaches (pp. 53-76). (Advances in Experimental Medicine and Biology; Vol. 746). https://doi.org/10.1007/978-1-4614-3146-6_5