Mechanisms of immunopathology in murine models of central nervous system demyelinating disease

Anne M. Ercolini, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reported to play important roles in myelin destruction. Numerous murine demyelinating models, both virus-induced and/or autoimmune, are available, which reflect the clinical and pathological variability seen in human disease. This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models.

Original languageEnglish (US)
Pages (from-to)3293-3298
Number of pages6
JournalJournal of Immunology
Volume176
Issue number6
DOIs
StatePublished - Mar 15 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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