Mechanisms of Neuronal Computation in Mammalian Visual Cortex

Nicholas J. Priebe, David Ferster*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations

Abstract

Orientation selectivity in the primary visual cortex (V1) is a receptive field property that is at once simple enough to make it amenable to experimental and theoretical approaches and yet complex enough to represent a significant transformation in the representation of the visual image. As a result, V1 has become an area of choice for studying cortical computation and its underlying mechanisms. Here we consider the receptive field properties of the simple cells in cat V1-the cells that receive direct input from thalamic relay cells-and explore how these properties, many of which are highly nonlinear, arise. We have found that many receptive field properties of V1 simple cells fall directly out of Hubel and Wiesel@s feedforward model when the model incorporates realistic neuronal and synaptic mechanisms, including threshold, synaptic depression, response variability, and the membrane time constant.

Original languageEnglish (US)
Pages (from-to)194-208
Number of pages15
JournalNeuron
Volume75
Issue number2
DOIs
StatePublished - Jul 26 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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