Mechanisms of premature closure of cranial sutures

Tord D. Alden*, Kant Y. Lin, John A. Jane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Craniosynostosis is defined as premature closure of the sutures of the skull, resulting in cranial deformity. Since Virchow's original paper describing the relationship between premature suture closure and skull morphology, we have learned much about the underlying mechanisms and consequences of premature suture closure. In this paper we will describe the biology of suture closure, the rules governing the resulting phenotypes seen clinically, and a prospective study of skull growth during the 1st year of life.

Original languageEnglish (US)
Pages (from-to)670-675
Number of pages6
JournalChild's Nervous System
Issue number11-12
StatePublished - Nov 1999


  • Craniostenosis
  • Craniosynostosis
  • Premature suture closure
  • Sagittal synostosis
  • Skull growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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