Mechanisms of pulmonary edema clearance

Gökhan M. Mutlu, Jacob I. Sznajder*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations

Abstract

The mechanisms of pulmonary edema resolution are different from those regulating edema formation. Absorption of excess alveolar fluid is an active process that involves vectorial transport of Na+ out of alveolar air spaces with water following the Na+ osmotic gradient. Active Na + transport across the alveolar epithelium is regulated via apical Na+ and chloride channels and basolateral Na-K-ATPase in normal and injured lungs. During lung injury, mechanisms regulating alveolar fluid reabsorption are inhibited by yet unclear pathways and can be upregulated by pharmacological means. Better understanding of the mechanisms that regulate edema clearance may lead to therapeutic interventions to improve the ability of lungs to clear fluid, which is of clinical significance.

Original languageEnglish (US)
Pages (from-to)L685-L695
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume289
Issue number5 33-5
DOIs
StatePublished - Nov 2005

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • Alveolar epithelium
  • Alveoli lung

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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